| Acronym | Sense | Language | Topics |
|---|---|---|---|
| LES | Launch Equipment Shop | In English | → Spaceflight engineering, astronautics |
| LES | Launch Escape Subsystem | In English | → Spaceflight engineering, astronautics |
| LES | Launch-Entry Suit | In English | → Spaceflight engineering, astronautics |
| LES | Leading Edge Subsystem | In English | |
| LES | Lincoln Experimental Satellite | In English | → Spaceflight engineering, astronautics |
| LES | Logistic Execution System | In English | → Maintenance and logistics |
| LES | Lupus Érythémateux Systémique = SLE | Systemic Lupus Erythematosus | In English |
In French | → Immunology and allergy → Pathology |
| LES | Lucerna Esperanto-Societo | In Esperanto | → Organizations and associations |
| LES | Laŭzana Esperanto Societo | In Spanish | → Organizations and associations |
| LES | Large Eddy Simulation | In English | → Computer simulation |
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