| AIMSUN2 | Advanced Interactive Microscopic Simulator for Urban and Non-Urban Networks | In English | → Transport and postal services |
| ARSC | Arctic Region Supercomputing Center | In English | |
| ASCOT | Advanced Scientific Computing Team | In English | → 5196 |
| CADAM | Computer Graphics Augmented Design and Manufacturing | In English | |
| CADDS | Computer-Aided Design and Drafting System | In English | |
| CUG | Cray User Group | In English | |
| DFS | Dynamic Flight Simulator | In English | → Aeronautics, aircraft → Spaceflight engineering, astronautics |
| DRACULA | Dynamic Route Assignment Combining User Learning and Microsimulation | In English | → Transport and postal services |
| ECSS | Extendable Computer System Simulator | In English | |
| ESCS | Electronic Spacecraft Simulator | In English | → Spaceflight engineering, astronautics |
| GVN | Grand Versailles Numérique (www.gvn.chateauversailles.fr) | In French | → Museums |
| HCSL | Hybrid Computation and Simulation Laboratory | In English | → Research institutes |
| HEDSIM | High Endoatmospheric Event-Based Simulation | In English | |
| HEDSIM | High Endoatmospheric Defense System Simulator | In English | → Military engineering |
| HESS | High-Energy Squib Simulator | In English | → Physics |
| HSL | Hardware Simulation Laboratory | In English | → Research institutes → Hardware |
| HUTSIM | Helsinki University of Technology Simulator | In English | |
| ICS | Interpretive Computer Simulator | In English | |
| IJMoS | International Journal of Modelling and Simulation | In English | → Serial publications, periodicals |
| IRRMA | Institut Romand de Recherche Numérique en Physique de Matériaux | In French | → Physics |
| ITS | Intercept Trajectory Simulation | In English | → Vehicle engineering |
| MACSI | Mathematics, Computing and Simulation for Industry | In English | → Mathematics → Computer science |
| MComM | Mathematical and Computer Modelling | In English | → Serial publications, periodicals → Mathematics |
| MDS | Mission Development Simulator | In English | |
| MELROSE | Mitsubishi Electric Road Traffic Simulation Environment | In English | → Transport and postal services |
| MICSTRAN | Microscopic Simulator Model for Traffic Networks | In English | → Transport and postal services |
| MITSIM | Microscopic Traffic Simulator | In English | → Transport and postal services |
| NAS | Nonavionics Simulator | In English | → Aeronautics, aircraft |
| NAS | Numerical Aerodynamic Simulation | In English | → Aerodynamics |
| NETSIM | Network Simulation | In English | |
| NSS | Network Simulation System | In English | → Networks, communication |
| ODE | Open Dynamics Engine (www.ode.org) | In English | → Software → Image processing |
| OFDS | Orbiter Flight Dynamic Simulator | In English | → Spaceflight engineering, astronautics |
| PADSIM | Probabilistic Adaptive Simulation Model | In English | |
| RIDS | Rockwell Integrated Defense Simulator | In English | → Military affairs |
| RMS | Random Motion Simulator | In English | |
| RTSF | Real-Time Simulation Facility | In English | |
| RTSS | Real-Time Simulation System | In English | |
| SAMS | Systems Analysis Modelling Simulation | In English | → Serial publications, periodicals |
| SCC | Simulation Configuration Control | In English | |
| SCSS | Satellite Control Simulation System | In English | → Spaceflight engineering, astronautics |
| SDF | Simulation Data File | In English | |
| SDS | Simulation Data Subsystem | In English | |
| SEG | Simulation Engineering Group | In English | → Engineering, technology |
| SHIVA | Simulated Highways for Intelligent Vehicle Algorithms | In English | → Transport and postal services |
| SHLB | Simulation Hardware Load Box | In English | → Hardware |
| SHS | Simulation Hardware System | In English | → Hardware |
| SIB | Simulation Interface Buffer | In English | → Human-computer interaction |
| SISTM | Simulation of Strategies for Traffic on Motorways | In English | → Transport and postal services |
| SOC | Simulation Operation Computer | In English | |
| SPAF | Simulation Processor and Formatter | In English | |
| SPCU | Simulation Process Control Unit | In English | |
| SSH | Simulation Support Hardware | In English | → Hardware |
| USOC | Unified System Orbit Computation | In English | → Serial publications, periodicals → Astronomy |
| VSI | Video Simulation Interface | In English | → Human-computer interaction |
| XMDS | eXtensible Multi-Dimensional Simulator | In English | → Mathematics |
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