Space transport engineering, spaceflight engineering, astronautics, astronautical engineering, cosmonautics, rocketry, spacecraft, rockets and missiles.
| Acronym | Sense | Language | Topics | 
|---|---|---|---|
| SERIESX | Satellite Emission Range Infrared Earth Sent | In English | |
| SERS | Shuttle Enhanced Reconfiguration System | In English | |
| SERS | Shuttle Equipment Record System | In English | |
| SERT | Space Electrical Rocket Test | In English | → Electrical engineering | 
| SES | Satellite Earth Stations & Systems | In English | |
| SES | Shuttle Engineering Simulation | In English | |
| SES | Shuttle Engineering Simulator | In English | |
| SESAR | Single European Sky ATM Research | In English | → Aeronautics, aircraft | 
| SESC | Shuttle Events Sequential Control | In English | |
| SESL | Space Environment(al) Simulation Laboratory | In English | → Research institutes | 
| SESP | Space Experiment to Support Program | In English | |
| SEWS | Satellite Early Warning System | In English | |
| SFA | Sun-Finder Assembly | In English | |
| SFACI | Software Flight Article Configuration Inspection | In English | → Software → Aeronautics, aircraft  | 
| SFCS | Survival Flight Control System | In English | → Aeronautics, aircraft | 
| SFO | Space Flight Operations | In English | |
| SFOF | Space Flight Operations Facility | In English | |
| SFOM | Shuttle Flight Operations Manual | In English | |
| SFOM | Space Flight Operations Memorandum | In English | |
| SFOP | Space Flight Operations Plan | In English | |
| SFP | Summary Flight Plan | In English | → Aeronautics, aircraft | 
| SFS | Shuttle Flight Status | In English | |
| SFSS | Satellite Field Service Station | In English | |
| SFT | Simulated Flight Test | In English | → Aeronautics, aircraft | 
| SGC | Stabilized Ground Cloud | In English | → Meteorology, climatology | 
| SGITS | Spacecraft/GOSS Interface Test System | In English | |
| SGLS | Space-Ground Link Station | In English | → Telecommunications | 
| SGLS | Space-Ground Link System | In English | → Telecommunications | 
| SGOS | Shuttle Ground Operations Simulator | In English | |
| SI | Shuttle Integration | In English | |
| SI/FS | System Integration and Flight Software | In English | → Software → Aeronautics, aircraft  | 
| SID | Shuttle Integration Device | In English | |
| SIDC | Space Innovation and Development Center | In English | → Research institutes → Astronomy  | 
| SIE | Shuttle Interface Equipment | In English | → Human-computer interaction | 
| SILTS | Shuttle Infrared Lee-Side Temperature Sensing | In English | |
| SIMAS | Shuttle Information Management Accountability System | In English | |
| SIMS | Shuttle Imaging Microwave System | In English | |
| SIMS | Shuttle Inventory Management System | In English | → Maintenance and logistics | 
| SIO | Staged In Orbit | In English | |
| SIP | Strain Isolation Pad | In English | |
| SIR | Shuttle Imaging Radar | In English | |
| SIRTF | Shuttle Infrared Telescope Facility | In English | → Astronomy | 
| SIS | Shuttle Information Service | In English | → Knowledge management | 
| SIS | Shuttle Information System | In English | → Knowledge management | 
| SIS | Shuttle Integration Schedule | In English | |
| SIS | Shuttle Interface Simulator | In English | → Human-computer interaction | 
| SISEX | Shuttle Imaging Spectrometer Experiment | In English | → Astronomy → Analytical chemistry  | 
| SIT | Shuttle Integrated Test | In English | |
| SIT | Shuttle Interface Test | In English | |
| SITE | Spacecraft Instrumentation Test Equipment | In English | |
| SIVE | Spacelab Interface Verification Equipment | In English | |
| SJC | Spacecraft Jettison Controller | In English | |
| SL | Space Laboratory | In English | → Research institutes | 
| SL | Space Launch | In English | |
| SL | Spacelab | In English | |
| SLAENG | Space-Based Laser Engagement | In English | |
| SLAMAP | Space Laser Mission Analysis Program | In English | |
| SLC | Space Launch Complex | In English | |
| SLCA | Spacelab Contract Administration | In English | |
| SLCM | Spacelab Configuration Management | In English | |
| SLCSAT | Submarine Laser Communications Satellite | In English | |
| SLED | Space Laser Experiment Definition | In English | |
| SLEMU | Spacelab Engineering Model Unit | In English | |
| SLF | Shuttle Landing Facility | In English | |
| SLM | Space Laboratory Module | In English | → Research institutes | 
| SLODB | Spacelab Operational Data Book | In English | |
| SLPB | Spacelab Program Board | In English | |
| SLS | Secondary Landing Site | In English | → Aeronautics, aircraft | 
| SLS | Spacelab Simulator | In English | |
| SLSA | Shuttle Logistics Support Aircraft | In English | → Maintenance and logistics → Aeronautics, aircraft  | 
| SLSMS | Spacelab Support Module Simulator | In English | |
| SLSS | Spacelab Subsystem | In English | |
| SLUK | Spacelab Utility Kit | In English | |
| SLV | Space Launch Vehicle | In English | |
| SM | Shuttle Management | In English | |
| SMATH | Satellite Materials And Target Hardening | In English | |
| SMB | Space Meteorology Branch | In English | → Meteorology, climatology | 
| SMCC | Shuttle Mission Control Center | In English | |
| SMD | Spacelab Mission Development | In English | |
| SMES | Shuttle Mission Engineering Simulator | In English | |
| SMES | Shuttle Mission Evaluation Simulation | In English | |
| SMG | Space Flight Meteorology Group | In English | → Meteorology, climatology | 
| SMIRR | Shuttle Multispectral Infrared Radiometer | In English | |
| SML | Spacecraft Markup Language | In English | → Programming languages | 
| SMPTRB | Shuttle Main Propulsion Test Requirement Board | In English | → Organizations and associations | 
| SMS | Shuttle Mission Simulator | In English | |
| SMS | Solar Maximum Satellite | In English | |
| SMS | Synchronous Meteorological Satellite | In English | → Meteorology, climatology | 
| SMSCC | Shuttle Mission Simulator Computer Complex | In English | → Computer hardware | 
| SMSG | Shuttle Maintenance Steering Group | In English | → Organizations and associations → Maintenance and logistics  | 
| SMTAS | Shuttle Modal Test and Analysis System | In English | |
| SMTF | Shuttle MIssion Trainer Facility | In English | |
| SMVP | Shuttle Master Verification Plan | In English | → Quality management | 
| SMVRD | Shuttle Master Verification Requirements Document | In English | → Quality management | 
| SN | Space Network | In English | → Astronomy | 
| SNAP | Space Nuclear Auxiliary Power | In English | → Nuclear technology | 
| SNIAS | Société Nationale Industrielle Aéronautique et Spatiale | In French | → Aeronautics, aircraft | 
| SNPO | Space Nuclear Propulsion Office | In English | → Nuclear technology | 
| SNS | Shuttle Network System | In English | |
| SNSO | Space Nuclear Systems Office | In English | → Nuclear technology | 
| SO | Shuttle Operations | In English | |
| SO/SI | Space Operations and Scientific Investigation | In English | → Astronomy | 
| SOAR | Shuttle Orbital Applications and Requirements | In English | |
| SOARS | Shuttle Operation Automated Reporting System | In English | → Knowledge management | 
| SOC | Shuttle Operations Center | In English | |
| SOC | Space Operations Center | In English | |
| SOCAR | Shuttle Operational Capability Assessment Report | In English | → Quality management | 
| SOCC | Satellite Operations Control Center | In English | |
| SOCC | Shuttle Operations Computing Center | In English | → Computer science | 
| SOCH | Spacelab Orbiter Common Hardware | In English | → Computer hardware | 
| SODB | Shuttle Operational Data Book | In English | |
| SODS | Shuttle Operational Data Submittal | In English | → Data | 
| SODS | Shuttle Operational Data System | In English | → Data | 
| SODS | Skylab Orbit-Deorbit System | In English | |
| SOF | Safety Of Flight | In English | → Accidents, risks, safety → Aeronautics, aircraft  | 
| SOFC | Solid Oxyd Fuel Cell | In English | |
| SOFT | Space Operations and Flight Technique | In English | → Aeronautics, aircraft | 
| SOFT | Suborbit Flight Test | In English | → Aeronautics, aircraft | 
| SOI | Space Object Identification | In English | |
| SOIS | Spacelab/Orbiter Interface Simulator | In English | → Human-computer interaction | 
| SOM | Suborbital Mission | In English | |
| SOMS | Shuttle Orbiter Medical System | In English | → Medicine | 
| SOP | Spacecraft Operations Plan | In English | |
| SOP | Spacelab Opportunity Payload | In English | |
| SOPC | Shuttle Operations and Planning Center | In English | |
| SOPEMEA | Société pour le Perfectionnement des Matériels et Équipements Aérospatiaux | In French | → Aeronautics, aircraft → France  | 
| SOR | Stable Orbit Rendezvous | In English | |
| SOS | Synchronous-Orbit Satellite | In English | |
| SOSI | Space Operations Scientific Investigation | In English | |
| SOSMAN | Space Operations System Manifesting Program | In English | |
| SOSRM | Strap-On Solid Rocket Motor | In English | |
| SOT | Solar Optical Telescope | In English | → Astronomy | 
| SOTS | Suborbital Tank Separation | In English | |
| SP | Surveillance Payload | In English | |
| SP | Solid Propellant | In English | |
| SP | Sortie Payload | In English | |
| SPA | Small-Payload Accommodations | In English | |
| SPA | Space Processing Application | In English | |
| SPACE | Spacecraft Prelaunch Automatic Checkout Equipment | In English | |
| SPAD | Shuttle Payload Accommodation Document | In English | |
| SPADATS | Space Defense Acquisition and Tracking System | In English | → Military engineering | 
| SPADCCS | Space Defense Command and Control System | In English | → Military engineering | 
| SPADE | Space Acquisition Defense Experiment | In English | → Military engineering | 
| SPADOC | Space Defense Operations Center | In English | → Military engineering | 
| SPADS | Shuttle Problem Analysis Data System | In English | |
| SPAH | Spacelab Payload Accommodations Handbook | In English | |
| SPAN | Spacecraft Analysis | In English | |
| SPAR | Shuttle Pointed Autonomous Research | In English | |
| SPARS | Space Precision Attitude Reference System | In English | |
| SPART | Space Research And Technology | In English | → Astronomy | 
| SPARTAN | Shuttle Pointed Autonomous Research Tool for Astronomy | In English | → Astronomy | 
| SPAS | Space Pallet Satellite | In English | |
| SPAS | Shuttle Pallet Applications System | In English | |
| SPAS | Shuttle Pallet Satellite | In English | |
| SPAT | Satellite Performance Analysis Team | In English | |
| SPAT | Small-Payload Accommodation Terminal | In English | |
| SPC | Shuttle Processing Contract(or) | In English | |
| SPDS | Stabilized Payload Deployment System | In English | |
| SPF | Spacelab Processing Facility | In English | |
| SpFl | Spaceflight | In English | → Serial publications, periodicals | 
| SPGAI | Surface Position Gimbal Angle Indicator | In English | |
| SPICE | Shuttle Payload Integration Cargo Evaluation | In English | |
| SPICE | Spacelab Payload Integration and Coordination in Europe | In English | |
| SPICE | Survey Probe Infrared Celestial Experiment | In English | → Astronomy | 
| SPICE | Survey Program of Infrared Celestial Experiments | In English | → Astronomy | 
| SPIDPO | Shuttle Payload Integration and Development Program Office | In English | |
| SPIDS | Stabilized Payload Interface Deployment System | In English | |
| SPIF | Shuttle Payload Integration Facility | In English | |
| SPIF | Shuttle Processing Interface Facility | In English | |
| SPIF | Standard Payload Interface | In English | |
| SPII | Shuttle Program Implementation Instruction | In English | |
| SPIMS | Shuttle Program Information Management System | In English | → Knowledge management | 
| SPIRE | Spectral Infrared Rocket Experiment | In English | → Astronomy | 
| SPIRIT | Spatial Infrared Telescope | In English | → Astronomy | 
| SPL | Secondary Payload | In English | |
| SpMar | Space Markets | In English | → Serial publications, periodicals → Astronomy  | 
| SpMME | Space Medicine Medical Engineering | In English | → Serial publications, periodicals → Medicine  | 
| SPN | Shuttle Project Notice | In English | |
| SPO | Shuttle Program Office | In English | |
| SPO | Spacecraft Program Office | In English | |
| SPOC | Shuttle Payload Operations Contract | In English | |
| SPOC | Shuttle Portable On-Board Computer | In English | → Computer hardware | 
| SPORTS | Simplified Payload/Orbiter Thermal Simulator | In English | |
| SPOT | Système Probatoire d'Observation de la Terre | In French | → Earth sciences → France  | 
| SPOT | Système Probatoire pour l'Observation de la Terre | In French | → Meteorology, climatology | 
| SPOT | Space Station Proximity Operations Trainer | In English | |
| SPP | SImulation Planning Panel | In English | → Aeronautics, aircraft | 
| SPP | Solar Physics Payload | In English | → Astronomy | 
| SPPIL | Shuttle Preferred Pyrotechnic Items List | In English | |
| SpPol | Space Policy | In English | → Serial publications, periodicals → Astronomy  | 
| SpPow | Space Power | In English | → Serial publications, periodicals → Energy economics  | 
| SPRAG | STS Payload Requirements and Analysis Group | In English | → Organizations and associations | 
| SpRBu | Space Research Bulgaria | In English | → Serial publications, periodicals → Astronomy  | 
| SPRMD | Space Power Resources and Manufacturing Development | In English | → Serial publications, periodicals → Energy economics  | 
| SPS | Satellite Power System | In English | → Energy economics | 
| SPS | Shuttle Procedures Simulator | In English | |
| SPS | Shuttle Processing Site | In English | |
| SPSL | Space Parts Selection List | In English | → Maintenance and logistics | 
| SPT | Stationnary Plasma Thruster | In English | → Electrical engineering | 
| SPVPF | Shuttle Payload VeErtical Processing Facility | In English |