

| Acronym | Sense | Language | Topics | 
|---|---|---|---|
| PBIM | Programmable Buffer Interface Module | In English | → Human-computer interaction | 
| PBL | Policy Block List | In English | → Networks, communication | 
| PBS | Portable Batch System | In English | → Networks, communication | 
| PBS | Print Batch Services | In English | → Peripheral devices | 
| PC&PM | Program Control and Performance Management | In English | |
| PC-DOS | Personal Computer Disk Operating System | In English | → Operating systems | 
| PCGI | Perl Common Gateway Interface | In English | → Programming languages → Networks, communication | 
| PCL | Programming Checklist | In English | |
| PCRE | Perl-Compatible Regular Expression | In English | |
| PCS | Professional Clinical Software | In English | → Medicine | 
| Portable Document Format | In English | → Programming languages → Data → Document processing | |
| PDL | Plan de Développement Logiciel | In French | |
| PDSDL | Python-based Dynamic System Description Language | In English | → Programming languages | 
| PEM | Privacy Enhanced Mail | In English | |
| PERL | Practical Extraction and Report Language | In English | → Computer programs | 
| PESSL | Parallel Engineering and Scientific Subroutine Library | In English | → Programming languages → Mathematics and natural sciences → Engineering, technology | 
| PFS | Primary Flight Software | In English | → Aeronautics, aircraft → Astronautics | 
| PGC | Progiciel de Gestion du Contenu | In French | → Knowledge management | 
| PGI | Progiciel de Gestion Intégrée | In English | |
| PGI | Progiciel de Gestion Intégré | In French | |
| PGML | Precision Graphics Markup Language | In English | → Programming languages → Image processing | 
| PHP | Personal Home Page | In English | → Programming languages → Networks, communication | 
| PHP | PHP Hypertext Preprocessor | In English | → Programming languages → Networks, communication | 
| PHP/FI | Personal Home Page Tools/Form Interpreter | In English | → Programming languages | 
| PICO | Program In, Chip Out | In English | → Computer hardware | 
| PIDS | Protocol-based Intrusion Detection System | In English | |
| PL/1 | Programming Language number 1 | In English | → Programming languages | 
| PL/M | Programming Language for Microcomputers | In English | |
| PLDI | Programming Language Design and Implementation | In English | → Programming languages | 
| PLEAC | Programming Language Examples Alike Cookbook | In English | → Programming languages | 
| PLUG | Provence Linux Users Group | In English | → Operating systems | 
| PMAC | Portable Multipurpose Applications Console | In English | → Human-computer interaction | 
| PMS | Property Management System | In English | |
| PMT | Pre-emptive Multitasking | In English | → Operating systems | 
| POA | Pilote Opérationnel d'Application | In French | → Management | 
| POJO | Plain Old Java Object | In English | → Programming languages | 
| POJO | Plain Old Java Objects | In English | → Programming languages | 
| POLUX | Production Optimisée de Livrables UML et XML | In French | |
| POP | Parallel Ocean Program | In English | → Computer programs → Marine research, oceanography | 
| POP | Post Office Protocol | In French | → Networks, communication | 
| PORTALIS | POste de Référence Technique d'Accès aux Logiciels, Informations et Services | In French | → Computer hardware | 
| POSIX | Portable Operating System Interface | In English | → Human-computer interaction | 
| POWDER | Protocol for Web Description Resources | In English | → Internet | 
| PPCP | Postprocessing Computer Program | In English | → Computer programs | 
| PPI | Pixel Per Inch | In English | → Operating systems | 
| PPM | Perl Package Manager | In English | |
| PPN | Project Programmer Number | In English | |
| PPS | Primer Pair Selection | In English | → Biotechnology → Genetics → Biochemistry, biophysics | 
| PRAI | Pattern Recognition and Artificial Intelligence | In English | |
| PRATIC | PRocédure d'Analyse et de Traitement des Informations Commerciales | In French | → Trade → Energy economics | 
| PROGRESS | Programme for Research on Embedded Systems & Software | In English | → Electronics | 
| PROLOG | PROgrammation LOGique | In French | → Programming languages | 
| PRPS | Programming Requirements Process Specification | In English | |
| PS | PostScript | In English | → Programming languages → Document processing | 
| PSE | Primer Specificity Evaluation | In English | → Biotechnology → Genetics → Enzymes | 
| PSICOSE | Participation du Système d'Information à la COmpréhension du Social dans l'Entreprise | In French | → Personnel management | 
| PSL | Program Support Library | In English | |
| PSL | Program Statement Language | In English | → Programming languages | 
| PSO | Phantasy Star Online | In English | → Entertainment | 
| PSP | Programmable Signal Processor | In English | → Telecommunications | 
| PSU | Phantasy Star Universe | In English | → Entertainment | 
| PUP | Potentially Unwanted Program | In English | |
| PVS | Passive Vulnerability Scanner | In English | |
| QDOS | Quick and Dirty Operating System | In English | → Operating systems | 
| QOM | Quick Ontology Mapping | In English | |
| R2ML | REWERSE Rule Markup Language | In English | → Computer hardware | 
| RACF | Resource Access Control Facility | In English | |
| RAD | Rapid Application Development | In English | |
| RADOP | Radiator Optimization Computer Code | In English | |
| RAII | Resource Acquisition Is Initialization | In English | |
| RASMUS | Remote Accessible Software configurable Multi-channel Ultrasound Sampling system | In English | → Diagnostics | 
| RCP | Rich Client Platform | In English | |
| RCP | Rémunération pour Copie Privée | In French | → Cinema, movies | 
| RCS | Revision Control System | In French | |
| RDA | Rich Desktop Application | In English | |
| RDDL | Resource Directory Description Language | In English | → Programming languages → Data | 
| RDM | Real-Time Data Manager | In English | → Data | 
| RDOS | Real-Time Disk Operating System | In English | → Operating systems | 
| REWERSE | Reasoning on the Web with Rules and Semantics | In English | → Internet → Artificial intelligence → Semiotics | 
| REX | Remote Events for XML | In English | → Networks, communication | 
| RFCP | Request For Computer Program | In English | → Computer programs | 
| RGC | Retro-Gaming Connexion | In English | → Entertainment | 
| RGI | Référentiel Général d'Interopérabilité | In French | |
| RIA | Rich Internet Application | In English | → Internet | 
| RICP | Real-Time Interactive Computer Program | In English | → Computer programs | 
| RIS | Rauminformationssystem | In German | → Geography | 
| RNTL | Réseau National des Technologies Logicielles | In French | → Organizations and associations | 
| RNTL | Réseau National de Recherche et d'Innovation en Technologies Logicielles | In French | |
| ROSES | Rockwell Operational Software Engineering System | In English | |
| ROSS/V | RSTS/E Operating System Simulator for VAX | In English | → Operating systems | 
| RPG | Report Program Generator = GAP | Générateur Automatique de Programmes | In French | In English | → Programming languages | 
| RPL | Reverse Polish Lisp | In English | → Programming languages | 
| RSCS | Remote Spooling and Communication Subsystem | In English | → Networks, communication | 
| RSL | Requirements Specification Language | In English | → Programming languages → Management | 
| RSTS | Resource Sharing Time Sharing System | In English | → Operating systems | 
| RSTS/E | Resource Sharing Timesharing System Extended | In English | |
| RTCPS | Real-Time Computer Program System | In English | → Computer programs | 
| RTCS | Real-Time Computer System | In English | → Computer hardware | 
| RTFSS | Real-Time Flight Safety Software | In English | → Accidents, risks, safety → Aeronautics, aircraft → Astronautics | 
| RTOS | Real-Time Operating System | In English | → Operating systems | 
| RTS | Run Time System | In English | |
| RTSS | Resource Time Sharing System | In English | |
| RuleML | Rule Markup Language | In English | → Programming languages | 
| SaaS | Software as a Service | In English | → Networks, communication | 
| SABRE | Semi-Automatic Business Research Environment | In English | → Transport and postal services → Tourism | 
| SAC | Système d'Aide au Commandement | In French | → Military affairs | 
| SACRE | Système d'Aide au Choix de REnouvellement (des canalisations en fontes grises) | In French | → Energy economics | 
| SACS | Software Avionics Command Support | In English | → Aeronautics, aircraft | 
| SAEIV | Système d’Aide à l’Exploitation et à l’Information Voyageurs | In French | → Rail transport engineering → Rail transport → France | 
| SAETR | Serveur d’Aide à l’Exploitation Temps Réel | In French | → Rail transport → France | 
| SAGACE | Système Automatisé de Gestion Administrative Comptable Élaboré | In French | → Accounting | 
| SAGACE | Système d'Aide à la Gestion Automatisée des Concours Externes | In French | → Education | 
| SAIMAFOR | Système d'Aide Informatisée pour la Maîtrise des Actions de Formation | In French | → Education | 
| SAINT | Security Administrator’s Integrated Network Tool | In English | → Networks, communication | 
| SALUG | Savoie-Aravis Linux Users Group | In English | → Organizations and associations → Operating systems | 
| SAM | Système d'Acquisition de Mesures | In French | |
| SAML | Security Assertion Markup Language | In English | → Programming languages → Data | 
| SAMOA | Serveurs Applicatifs, Méthodes et Outils d'Administration | In French | |
| SAPHIR | Système d'Analyse Par HIstorisation du Retour d'expérience | In French | |
| SARA | Saisie de l'Activité Relative aux Agents | In French | → Management | 
| SARAH | Services distribués Asynchrones pour Réseaux Ad Hoc | In French | → Networks, communication | 
| SAS | Software Approval Sheet | In English | |
| SAS | Software Automation Subpanel | In English | |
| SASCB | Shuttle Avionics Software Control Board | In English | → Aeronautics, aircraft → Astronautics | 
| SASTP | Stand-Alone Self-Test Program | In English | |
| SBL | Spamhaus Block List | In English | → Networks, communication | 
| SBML | Systems Biology Markup Language | In English | → Programming languages → Biological sciences | 
| SBO | Systems Biology Ontology | In English | → Programming languages → Knowledge management → Libraries → Biological sciences | 
| SC | Software Change | In English | |
| SCA | Software Command Analysis | In English | |
| SCARE | The Source Code Analysis and Risk Evaluation | In English | → Programming languages | 
| SCATS | Sydney Co-ordinated Adaptive Traffic System | In English | → Transport and postal services | 
| SCB | Software Control Board | In English | |
| SCCB | Software Change Control Board | In English | |
| SCCB | Software Configuration Control Board | In English | |
| SCCH | Software Competence Center Hagenberg (www.scch.at) | In English | → Austria | 
| SCDR | Software Critical Design Review | In English | |
| SCEPTRE | Système de Collecte et consultation des Eléments de Personnel en TRansaction sur Écran-clavier | In French | → Maintenance and logistics | 
| SCI | Software Customer Inspection | In English | |
| SCM | Software Configuration Management/Manager | In English | |
| SCM | Sofware Configuration Management | In English | |
| SCMO | Software Configuration Management Office | In English | |
| SCMP | Software Configuration Management Plan | In English | |
| SCOM | Serveur de COMmunication | In French | → Networks, communication | 
| SCOS | Subsystem Computer Operating System | In English | → Operating systems | 
| SCR | Software Change Request | In English | |
| SCRB | Software Configuration Review Board | In English | |
| SCS | Solutions Communicantes Sécurisées | In French | → Networks, communication → Telecommunications | 
| SCSL | Scientific Computing Software Library | In English | |
| SDBC | Software Development Baseline Control | In English | |
| SDC | Software Development Computer | In English | → Computer hardware | 
| SDD | Software Description Document | In English | |
| SDD | Software Design Document | In English | |
| SDDD | Software Detailed Design Document | In English | |
| SDDL | Software Design and Document Language | In English | |
| SDE | Software Development Environment | In English | |
| SDF | Software Development Facility | In English | |
| SDF | Software Development File | In English | → Files | 
| SDH | Software Development Handbook | In English | |
| SDIF | Software Development and Integration Facility | In English | |
| SDK | Software Development Kit | In English | |
| SDL | System Description Language | In English | → Programming languages | 
| SDL | Simple Directmedia Layer | In English | |
| SDL | Software Development Laboratory | In English | → Research institutes | 
| SDL | Software Development Library | In English | |
| SDN | Software Development Note | In English | |
| SDP | Software Development Plan | In English | |
| SDR | Software Design Requirement | In English | |
| SDR | Software Design Review | In English | |
| SDRB | Software Design Review Board | In English | |
| SDS | Software Design Specification | In English | |
| SDVF | Software Development and Verification Facility | In English | |
| SE | Software Engineering | In English | |
| SE | Système d'Exploitation | In French | → Operating systems | 
| SEAL | Semantics-directed Environment Adaptation Language | In English | → Programming languages | 
| SEAL | Software-Optimized Encryption Algorithm | In English | → Algorithms | 
| SEAL | Software Engineering and Ada Lab(oratory) | In English | → Research institutes | 
| SEE | Software Engineering Exercise | In English | |
| SEE | Software Equality Evaluation | In English | |
| SEI | Software Engineering Institute | In English | |
| SELL | Syndicat des Éditeurs de Logiciel de Loisirs (https://www.sell.fr/) | In French | → Organizations and associations → Leisure → Entertainment → France | 
| SEM | SEmantic Memory | In English | → Semiotics | 
| SERIM | Software Engineering Risk Management | In English | → Management | 
| SES | Software Evaluation Subpanel | In English | |
| SES | Secure Entreprise Search | In English | |
| SES | Amazon Simple Email Service | In English | → Internet | 
| SEXI | String EXpression Interpreter | In English | → Programming languages | 
| SFACI | Software Flight Article Configuration Inspection | In English | → Aeronautics, aircraft → Astronautics | 
| SFLC | Software Freedom Law Center | In English | → Law, jurisprudence | 
| SFS | Self-certifying File System | In English | → Operating systems | 
| SGE | Système de Gestion des Échanges | In French | |
| SGE | Sun Grid Engine | In English | → Networks, communication | 
| SGML | Standard Generalized Markup Language | In English | → Programming languages → Data → Document processing | 
| SI | Sistema d'Informació = ИС | Информационная система | In Russian = IS | Informační systém | In Czech = IS | Information System | In English = SI | Système d'Information | In French = SI | Sistem Informasi | In Indonesian = IS | Informačný systém | In Slovak = IS | Informacijski sistem | In Slovenian | In Catalan | |
| SI | Système d'Information = ИС, IS (look above) | In French | |
| SI | Sistem Informasi = ИС, IS (look above) | In Indonesian | |
| SI/FS | System Integration and Flight Software | In English | → Aeronautics, aircraft → Astronautics | 
| SIA | Software Impact Assessment | In English | |
| SIC | Système d'Information Commerciale | In French | → Trade | 
| SICA | Système d'Information et de Commandement des Armées | In French | → Military affairs |