

| Acronym | Sense | Language | Topics | 
|---|---|---|---|
| SICF | Système d'Information pour le Commandement des Forces | In French | → Military affairs | 
| SICFD | Système d'Information Client Fournisseur du Distributeur | In French | → Energy economics | 
| SIE | Système d'Information Environnementale | In French | → Knowledge management → Environmental protection → Threats to the environment | 
| SIECLE | Serveur Intranet des Enquêtes CLientèle EDF-GDF | In French | → Trade → Energy economics | 
| SIFR | Scalable Inman Flash Replacement | In English | → Internet | 
| SIG | Système d'Information Géographique = GIS | Geographic(al) Information System | In English = SIG | Sistema Informativo Geografico | In Italian = SIG | Sistema de Información Geográfica | In Spanish = SIG | Sistema d'informació geogràfica | In Catalan = GIS | Geografický Informační Systém | In Czech = ГИС | Географска информационна система | In Bulgarian = ΓΣΠ | Γεωγραφικά Συστήματα Πληροφοριών | In Greek = GIS | Geographisches Informationssystem | In German = GIS | Geoinformationssystem | In German = GIS | Geoinfosüsteem | In Estonian = GIS | Geografski informacijski sustav | In Croatian = ממ"ג | מערכת מידע גאוגרפית | In Hebrew = GIS | Geografinė informacinė sistema | In Lithuanian = SIG | Sistem Informasi Geografis | In Indonesian = GIS | Geografisch Informatiesysteem | In Dutch = GIS | Geografiske informasjonssystem | In Nynorsk = GIS | Geografiske informasjonssystemer | In Norwegian = SIG | Sistema de informação geográfica | In Portuguese = ГИС | Географическая Информационная Система | In Russian = GIS | Geografski informacijski sistem | In Slovenian = GIS | Geografiskt InformationsSystem | In Swedish = ГІС | Геоінформаційна система | In Ukrainian | In French | → Databases → Knowledge management → Geography | 
| SIG | Sistema Informativo Geografico = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) | In Italian | → Databases → Knowledge management → Geography | 
| SIG | Sistema de Información Geográfica = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) | In Spanish | → Databases → Knowledge management → Geography | 
| SIG | Sistema d'informació geogràfica = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) | In Catalan | → Databases → Knowledge management → Geography | 
| SIG | Sistem Informasi Geografis = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) | In Indonesian | → Databases → Knowledge management → Geography | 
| SIG | Sistema de informação geográfica = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) | In Portuguese | → Databases → Knowledge management → Geography | 
| SIGB | Système Intégré de Gestion de Bibliothèque = ILS | Integrated Library System | In English = АБИС | Автоматизированные библиотечные информационные системы | In Russian | In French | → Knowledge management → Libraries | 
| SIL | Saved Image Library | In English | |
| SILL | Socle Interministériel de Logiciels Libres | In French | → Central administration → France | 
| SIMBL | SIMple Bundle Loader | In English | |
| SIOC | Système d'Information Opérationnel et de Commandement | In French | → Military affairs | 
| SIP | Software Input Panel | In English | |
| SIPB | Student Information Processing Board | In English | → Specialized or polytechnical colleges | 
| SIR | Système d'Information Régimentaire | In French | → Military affairs | 
| SIRR | Software Integration Readiness Review | In English | |
| SIRS | Système d'Information à Référence Spatiale | In French | → Geography | 
| SIS | Software Implementation Specification | In English | |
| SIS | Software Integrated Schedule | In English | |
| SIT | Sistema Informativo Territoriale = SIT | Système d'Information sur le Territoire | In French = SIT | System Informacji o Terenie | In Polish | In Italian | → Regional planning → Geography | 
| SIT | Système d'Information sur le Territoire = (look above) | In French | → Regional planning → Geography | 
| SIT | System Informacji o Terenie = (look above) | In Polish | → Regional planning → Geography | 
| SIT | Software Integrated Test | In English | |
| SITEL | Systèmes d'Information Terminaux Élémentaires | In French | |
| SLA | Service Level Agreement | In English | → Law, jurisprudence | 
| SLEE | Service Logic Execution Environment | In English | |
| SLPEM | Sparta Linear Programming Effectiveness Model | In English | |
| SLS | Softlanding Linux System | In English | → Operating systems | 
| SMBL | Systems Biology Markup Language | In English | → Programming languages → Data → Biological sciences | 
| SMIL | Synchronized Multimedia Integration Language | In English | → Programming languages → Computer-based techniques → Cinema, movies | 
| SMIT | System Management Interface Tool | In English | → Human-computer interaction | 
| SML | Spacecraft Markup Language | In English | → Programming languages → Astronautics | 
| SMP | Software Management Plan | In English | → Management | 
| SMS | Site-Managed Software | In English | |
| SMS | Software Modification Sheet | In English | |
| SMSC | Software Moding, Sequencing, and Control | In English | |
| SMU | Software Management Utility | In English | |
| SNARE | System iNtrusion Analysis and Reporting Environment | In English | |
| SNJV | Syndicat National du Jeu Vidéo | In French | → Organizations and associations → Entertainment | 
| SNOBOL | StriNg Oriented symBOlic Language (www.snobol4.org) | In English | → Programming languages | 
| SOCRATE | Système Offrant à la Clientèle la Réservation d'Affaires et de Tourisme en Europe | In French | → Transport and postal services → Tourism | 
| SOGo | Scalable OpenGroupware.org (http://sogo.opengroupware.org) | In English | |
| SOMM | Software Operations and Maintenance Manual | In English | |
| SOP | Subsystem Operating Program | In English | |
| SOPE | Skyrix Object Publishing Environment (http://sope.opengroupware.org) | In English | → Internet | 
| SORBS | Spam and Open Relay Blocking System | In English | → Networks, communication | 
| SP | Stored Procedure | In English | → Data | 
| SPA | Software Product Assurance | In English | |
| SPC | Software Productivity Consortium | In English | |
| SPC | Starting-Point Code | In English | |
| SPC | Stored Program Command | In English | |
| SPC | Stored Program Control | In English | |
| SPCR | Software Problem Change Request | In English | |
| SPD | SharePoint Designer | In English | |
| SPDR | Software Preliminary Design Review | In English | |
| SPE | Software Process Engineering | In English | |
| SPF | Software Production Facility | In English | |
| SPIP | Système de Publication pour l'Internet | In French | → Internet | 
| SPITBOL | SPeedy ImplemenTation of SNOBOL | In English | → Programming languages | 
| SPL | System Programming Language | In English | → Programming languages | 
| SPM | Software Programmer's Manual | In English | |
| SPM | Software Performance Monitor | In English | |
| SPR | Software Problem Report | In English | → Quality management | 
| SPS | Software Product Specification | In English | |
| SPS | Software Productivity Solution | In English | |
| SPT | System Planning Tool | In English | |
| SQA | Software Quality Assurance | In English | → Quality management | 
| SQE | Software Quality Evaluation | In English | → Quality management | 
| SQS | Amazon Simple Queue Service | In English | → Internet | 
| SRCB | Software Requirements Change Board | In English | |
| SRCBD | Software Requirements Change Board Directive | In English | |
| SREM | Software Requirements Methodology | In English | |
| SRN | Software Release Notice | In English | |
| SRR | Software Requirements Review | In English | → Quality management | 
| SRS | Software Requirements Specification | In English | → Quality management | 
| SS | System Software | In English | |
| SSA | Software Support Agency | In English | |
| SSA | Software Safety Analysis | In English | |
| SSAD | Software System Analysis Document | In English | |
| SSCR | Support Software Change Request | In English | |
| SSD | Spacecraft Software Division | In English | → Astronautics | 
| SSDD | Software System Design Document | In English | |
| SSDT | System Service Dispatch Table | In English | → Operating systems | 
| SSE | Software Support Environment | In English | |
| SSE | Software Support Equipment | In English | |
| SSEDF | Software Support Environment Development Facility | In English | |
| SSES | Software System Environment System | In English | |
| SSIDONI | Serveur d'Informations et de DONnées sur l'Informatique industrielle | In French | |
| SSIP | System Software Interface Processing | In English | → Human-computer interaction | 
| SSL | System Software Loader | In English | |
| SSML | Speech Synthesis Markup Language | In English | → Programming languages → Data | 
| SSO | Single Sign-On | In English | |
| SSO | Systems Software Office | In English | |
| SSP | Standard Switch Panel | In English | |
| SSPF | Space Shuttle Programming Facility | In English | → Astronautics | 
| SSPM | Software Standards and Procedures Manual | In English | |
| SSR | Software Specification Review | In English | |
| SSRN | System Software Reference Number | In English | |
| SSS | Spacecraft Software System | In English | → Astronautics | 
| STAR | Software Tools And Requirements | In English | |
| STARS | Software Technology for Adaptable and Reliable Systems | In English | |
| STD | Software Test Description | In English | |
| STIL | Software Test and Integration Laboratory | In English | → Research institutes | 
| STL | Sciences et Techniques du Logiciel | In French | |
| STLDD | Software Top-Level Design Document | In English | |
| STN | Software Trouble Note | In English | |
| STOICAL | STack Oriented Interactive Compiler Adapted to Linux | In English | → Operating systems | 
| STP | Software Technology Program | In English | |
| STP | Software Test Plan | In English | |
| STP | Software Test Procedure | In English | |
| STR | Software Test Report | In English | |
| SUL | Software Utilization List | In English | |
| SUM | Software User's Manual | In English | |
| SUN | Stanford University Network | In French | → Computer science → Computer hardware → Networks, communication → United States | 
| SURF | Système Utilitaire de Restitution de Fichier | In French | → Files | 
| SUSIE | Système Universel de Synchronisation Informatique Évolutif | In French | |
| SVG | Scalable Vector Graphics | In English | → Programming languages → Data → Graphical processing | 
| SVICP | Shock Vibration Information Center - Shock Vibration Computer Programs | In English | → Computer programs → Acoustics | 
| SVN | Subversion | In English | |
| SVP | Software Verification Procedure | In English | |
| SVRR | Software Verification Readiness Review | In English | |
| SW | Software | In English | |
| SWCDR | Software Critical Design Review | In English | |
| SWCI | Software Configuration Inspection | In English | |
| SWD&I | Software Development and Integration | In English | |
| SWEE | Software Engineering Environment | In English | |
| SWG | Software Working Group | In English | |
| SWL | Spamhaus White List | In English | → Networks, communication | 
| SWPDR | Software Preliminary Design Review | In English | |
| SWRL | Semantic Web Rule Language | In English | → Programming languages → Internet → Semiotics | 
| SWRR | Software Readiness Review | In English | |
| SWS | Software System | In English | |
| SWSF | Semantic Web Science Foundation | In English | → Foundations → Networks, communication → Language, linguistics, literature | 
| SWWG | Software Working Group | In English | |
| SYCOET | SYstème de COnfiguration des Équipements de Téléconduite (pour les réseaux de transport d'énergie) | In French | → Energy economics | 
| SYGAL | SYstème de Gestion Automatisée des Loyers | In French | → Accommodation | 
| SYGAL | SYstème de Gestion pour l'Alimentation | In French | → Food technology | 
| SYGARD | SYstème de Gestion d'Accès au Réseau de Distribution | In French | → Energy economics | 
| SYGMA | SYstème de Gestion de la MAintenance | In French | → Maintenance and logistics | 
| SYLVIE | SYstème de Listage et de Ventilation d'Informations Élaborées | In French | → Personnel management | 
| SYSFAC | SYstème de Surveillance de la FAtigue de la Chaudière | In French | → Nuclear technology | 
| T-FA | Two-Factor Authentication | In English | → Telecommunications | 
| TCE | Translation Control Entry | In English | → Memories | 
| TCL | Transaction Control language = LCT | Langage de Contrôle des Transactions | In French | In English | → Programming languages → Data | 
| TDA | Toullec Dancoing Associés | In French | |
| TDA | Transition Data Analysis | In English | → Mathematics → Statistics | 
| TextMD | Technical Metadata for Text | In English | → Documentation | 
| THAP | Thermal/Hydraulic Analyzer Digital Computer Program | In English | → Computer programs | 
| TIM | Time-based Inductive Machine | In English | |
| TLCSC | Top-Level Computer Software Component | In English | |
| TLP | Thread Level Parallelism | In English | |
| TMA | Tierce Maintenance Applicative | In French | |
| TMAPI | Common Topic Map Application Programming Interface | In English | → Semiotics → Linguistics | 
| TOAD | Tool for Application Developers | In English | |
| TOMS | Transactions on Mathematical Software | In English | → Serial publications, periodicals → Mathematics | 
| TOS | Tape Operating System | In English | → Operating systems | 
| TPMs | Technological Protection Measures | In English | → Artistic property | 
| TrAX | Transformation API for XML | In English | → Data | 
| TRML | Temporized Reader Markup Language | In English | → Computer-based techniques | 
| TROLL | Troupe Redonnaise Orientée Logiciel Libre | In French | → Operating systems | 
| TRS | Target Region Selection | In English | → Biotechnology → Genetics → Enzymes | 
| TSGP | Test Sequence Generator Program | In English | → Computer programs | 
| TSIS | Traffic Software Integrated System | In English | → Transport and postal services | 
| TSO | Time Sharing Option | In English | |
| TSP | Test Software Program | In English | → Computer programs | 
| TSP | Trajectory Shaping Program | In English | → Computer programs → Astronautics | 
| TSP | Trajectory Synthesis Program | In English | → Computer programs → Astronautics | 
| TSS | Test Software Support | In English | |
| TSS | Time Sharing System | In English | → Operating systems | 
| TSW | Test Software | In English | |
| TTCN | Tree and Tabular Combined Notation | In English | → Programming languages → Networks, communication | 
| TTX | TinyOS Technology Exchange | In English | → Congresses → Operating systems → Electronics | 
| UAM | User Authentification Module | In English | |
| UDA | User-Developed Application | In English | |
| UDIS | Unidad Docente de Ingeniería del Software | In Spanish | |
| UFD | User File Directory | In English | → Files | 
| UIMA | Unstructured Information Management Architecture | In English | |
| UIML | User Interface Markup Language | In English | → Programming languages → Human-computer interaction | 
| UOD | Unique Oligo Design | In English | → Biotechnology → Genetics → Enzymes | 
| UPF | Universal Patch Format | In English | |
| USI | Update Software Identity | In English | |
| UT | Unreal Tournament | In English | → Entertainment | 
| UUCP | Unix-to-Unix Copy | In English | → Operating systems | 
| VACM | VA Cluster Manager | In English | |
| VAPOR | Visualization and Analysis Platform for Ocean, atmosphere, and solar Researchers (www.vapor.ucar.edu) | In English | → Marine research, oceanography → Meteorology, climatology → Mathematics and natural sciences | 
| VB | Visual Basic | In English | → Programming languages | 
| VBA | Visual Basic for Applications | In English | → Programming languages | 
| VCL | Visual Component Library | In English | |
| VDI | Virtual Desktop Infrastructure | In English | |
| VLK | Volume License Key | In English | |
| VLM | Virtual Library Manager | In English | |
| VLP | Virtual Library Processor | In English | |
| VM | Virtual Memory | In English | → Memories | 
| VM | Virtual Machine | In English | |
| VML | Vector Markup Language | In English | → Programming languages → Image processing | 
| VMS | Virtual Memory System | In English | → Memories |