| SID | System Interface Document | In English | → Human-computer interaction |
| SID | Système d’Information Documentaire | In French | → Knowledge management |
| SIE | Système d'Information sur l'Eau | In French | → Knowledge management → Hydrology → 627 → Environmental technology, water supply, waste management |
| SIE | Shuttle Interface Equipment | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SIES | Supervision, Inspection, Engineering, and Services | In English | → Management → Engineering, technology |
| SIF | Service Informatique Fédéral | In French | → Computer science → Central administration |
| SIG | Sistema de Información Geográfica = GIS | Geographic(al) Information System | In English = SIG | Sistema Informativo Geografico | In Italian = SIG | Sistema d'informació geogràfica | In Catalan = GIS | Geografický Informační Systém | In Czech = ГИС | Географска информационна система | In Bulgarian = ΓΣΠ | Γεωγραφικά Συστήματα Πληροφοριών | In Greek = GIS | Geographisches Informationssystem | In German = GIS | Geoinformationssystem | In German = GIS | Geoinfosüsteem | In Estonian = GIS | Geografski informacijski sustav | In Croatian = ממ"ג | מערכת מידע גאוגרפית | In Hebrew = GIS | Geografinė informacinė sistema | In Lithuanian = SIG | Sistem Informasi Geografis | In Indonesian = GIS | Geografisch Informatiesysteem | In Dutch = GIS | Geografiske informasjonssystem | In Nynorsk = GIS | Geografiske informasjonssystemer | In Norwegian = SIG | Sistema de informação geográfica | In Portuguese = ГИС | Географическая Информационная Система | In Russian = GIS | Geografski informacijski sistem | In Slovenian = GIS | Geografiskt InformationsSystem | In Swedish = ГІС | Геоінформаційна система | In Ukrainian |
In Spanish | → Software → Geography |
| SIG | Sistema de informação geográfica = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Portuguese | → Software → Geography |
| SIG | Sistem Informasi Geografis = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Indonesian | → Software → Geography |
| SIG | Sistema d'informació geogràfica = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Catalan | → Software → Geography |
| SIG | Sistema Informativo Geografico = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Italian | → Software → Geography |
| SIG | Système d'Information Géographique = TAC | Traitement Communautaire Assertif | In French = PACT | Program Assertif Community Treatment | In English |
In French | → Software → Geography |
| SIGB | Système Intégré de Gestion de Bibliothèque = ILS | Integrated Library System | In English = АБИС | Автоматизированные библиотечные информационные системы | In Russian |
In French | → Knowledge management → Libraries → Software |
| SIGCHI | Special Interest Group on Computer–Human Interaction | In English | → Organizations and associations → Human-computer interaction |
| SIGLE | System for Information on Grey Literature in Europe | In English | → Libraries → Knowledge management |
| SII | Standards Institution of Israel | In English | → Standardization |
| SIL | Su'aalaha Intabadan La'isweydiiyey = FAQ | Frequently Asked Questions | In English = FAQ | Foire Aux Questions | In French = POD | Plej Oftaj Demandoj | In Esperanto |
In Somali | → Science and knowledge |
| SIM | Singapore Institute of Management | In English | → Management → Higher education, universities |
| SIM | Sistema Interamericano de Metrología | In Spanish | → Standardization |
| SIMAC | Semantic Interaction with Music Audio Contents | In English | → Computer-based techniques → Music |
| SIMS | Single Inventory Management System | In English | → Maintenance and logistics |
| SIN | Support Information Network | In English | → Networks, communication → Knowledge management |
| SINTEF | Selskapet for INdustriell og TEknisk Forskning | In Norwegian | → Research policy |
| SINTEF | Stiftelsen for industriell og teknisk forskning | In Norwegian | → Research policy → Engineering, technology |
| SIO | Serial Input/Output | In English | → Computer science |
| SIO | System Internetowy Olimpiady | In Polish | → Networks, communication |
| SIOgim | System Internetowy Olimpiady Gimnazjalistów | In Polish | → Networks, communication → Computer science |
| SIOP | Single Integrated Operational Plan | In English | → Management |
| SIOP | Single Integrated Operations Plan | In English | → Management |
| SIOP | Strategic Integrated Operations Plan | In English | → Management |
| SIP | Standard Interface Plan | In English | → Human-computer interaction |
| SIP | Strategic Information Plan | In English | → Knowledge management |
| SIP | Standard Interface Panel | In English | → Human-computer interaction |
| SIP | Software Input Panel | In English | → Software |
| SIP | Session Initiation Protocol | In English | → Networks, communication → Telecommunications |
| SIPB | Student Information Processing Board | In English | → Software → Specialized or (poly)technical colleges |
| SIRA | Système d'Informations pour la Recherche en Accidentologie | In French | → Data → Transport and postal services |
| SIRENE | Système Informatique pour le Répertoire des ENtreprises et Établissements | In French | → Computer-based techniques → Economics |
| SIRH | Systèmes d'Information Ressources Humaines | In French | → Personnel management → Labour, labour economics |
| SIRR | Software Integration Readiness Review | In English | → Software |
| SIRS | Système d'Information à Référence Spatiale | In French | → Software → Geography |
| SIS | Software Intensive System | In English | → Computer-based techniques |
| SIS | Standardiseringen i Sverige | In Swedish | → Standardization |
| SIS | Shuttle Information System | In English | → Knowledge management → Spaceflight engineering, astronautics |
| SIS | SAIL Interface System | In English | → Human-computer interaction |
| SIS | Simulator Interface System | In English | → Human-computer interaction |
| SIS | Software Implementation Specification | In English | → Software |
| SIS | Shuttle Information Service | In English | → Knowledge management → Spaceflight engineering, astronautics |
| SIS | Software Integrated Schedule | In English | → Software |
| SIS | Shuttle Interface Simulator | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SIS | Simulation Interface Subsystem | In English | → Human-computer interaction |
| SIS | Standard Interface Specification | In English | → Human-computer interaction |
| SISD | Simulation Interface and Standards Document | In English | → Human-computer interaction |
| SISR | Semantic Interpretation for Speech Recognition | In English | → Computer-based techniques → Linguistics |
| SIST | Slovenian Institute for Standardization | In English | → Standardization |
| SIST | Slovenski inštitut za standardizacijo | In Slovenian | → Standardization |
| SISTM | Simulation of Strategies for Traffic on Motorways | In English | → Computer simulation → Transport and postal services |
| SIT | Software Integrated Test | In English | → Software |
| SIT | Système d'Information sur le Territoire = SIT | Sistema Informativo Territoriale | In Italian = SIT | System Informacji o Terenie | In Polish |
In French | → Software → Regional planning → Geography |
| SIT | System Informacji o Terenie = (look above) |
In Polish | → Software → Regional planning → Geography |
| SIT | Sistema Informativo Territoriale = (look above) |
In Italian | → Software → Regional planning → Geography |
| SIU | Serial Interface Unit | In English | → Human-computer interaction |
| SIU | Signal Interface Unit | In English | → Human-computer interaction |
| SIU | Standard Interface Unit | In English | → Human-computer interaction |
| SKOS | Simple Knowledge Organisation Systems | In English | → Knowledge management |
| SKU | Stock-Keeping Unit | In English | → Maintenance and logistics |
| SL&I | System Load and Initialization | In English | → Computer science |
| SLA | Support and Logistics Areas | In English | → Maintenance and logistics |
| SLAHTS | Stowage List And Hardware Tracking System | In English | → Writing systems |
| SLAM | Station Logistics And Maintainability (database) | In English | → Maintenance and logistics |
| SLBS | Saint Lucia Bureau of Standards | In English | → Standardization |
| SLEE | Service Logic Execution Environment | In English | → Software |
| SLIP | Serial Line Internet Protocol | In English | → Networks, communication |
| SLPEM | Sparta Linear Programming Effectiveness Model | In English | → Software |
| SLS | Softlanding Linux System | In English | → Operating systems |
| SLSA | Shuttle Logistics Support Aircraft | In English | → Maintenance and logistics → Aeronautics, aircraft → Spaceflight engineering, astronautics |
| SLSI | Sri Lanka Standards Institution | In English | → Standardization |
| SM | Systems Management | In English | → Management → Engineering, technology |
| SMBD | Sistem manajemen basis data = DBMS | Data Base Management System | In English = SGBD | Système de Gestion de Base de Données | In French = SŘBD | Systém řízení báze dat | In Czech = SGBD | Sistema de Gestió de Bases de Dades | In Catalan = SUBP | Sustav za upravljanje bazom podataka | In Croatian = DBKS | Datu-baseak kudeatzeko sistema | In Basque = SGBD | Sistema de gestión de base de datos | In Spanish = DBMS | Datenbankmanagementsystem | In German |
In Indonesian | → Data |
| SMBL | Systems Biology Markup Language | In English | → Programming languages → Data → Biological sciences |
| SMCM | Small Module Core Memory | In English | → Memories |
| SMEK | Summary Message Enable Keyboard | In English | → Hardware |
| SMIG | Southern Minnesota Internet Group | In English | → Organizations and associations → Networks, communication |
| SMIL | Synchronized Multimedia Integration Language | In English | → Programming languages → Computer-based techniques → Cinema, movies |
| SMILES | Simplified Molecular Input Line Entry Specification | In English | → Data → Chemistry |
| SML | Spacecraft Markup Language | In English | → Programming languages → Spaceflight engineering, astronautics |
| SMM | Subcontract Management Manual | In English | → Management → 3474 |
| SMM | Subsystem Management Manual | In English | → Management → Engineering, technology |
| SMOC | Simulation Mission Operation Computer | In English | → Hardware |
| SMP | Software Management Plan | In English | → Software → Management |
| SMQ | Structure Module Qualification | In English | → Quality management |
| SMQ | Système de Management de la Qualité | In French | → Quality management |
| SMR | Source, Maintenance, and Recoverability | In English | → Maintenance and logistics |
| SMS | Software Modification Sheet | In English | → Software |
| SMS | Site-Managed Software | In English | → Software |
| SMSC | Software Moding, Sequencing, and Control | In English | → Software |
| SMSCC | Shuttle Mission Simulator Computer Complex | In English | → Hardware → Spaceflight engineering, astronautics |
| SMSG | Shuttle Maintenance Steering Group | In English | → Organizations and associations → Maintenance and logistics → Spaceflight engineering, astronautics |
| SMTP | Simple Mail Transfer Protocol | In English | → Networks, communication |
| SMU | Software Management Utility | In English | → Software |
| SMU | Singapore Management University | In English | → Management → Economics → Higher education, universities |
| SMVP | Shuttle Master Verification Plan | In English | → Quality management → Spaceflight engineering, astronautics |
| SMVRD | Shuttle Master Verification Requirements Document | In English | → Quality management → Spaceflight engineering, astronautics |
| SNA | System Network Architecture | In English | → Networks, communication |
| SNIMA | Service de Normalisation Industrielle Marocaine | In French | → Standardization |
| SNL | SYBYL Line Notation | In English | → Data → Chemistry |
| SNML | Salzburg NewMediaLab | In English | → Computer science → Telecommunications |
| SNMP | Simple Network Management Protocol | In English | → Internet |
| SNOBOL | StriNg Oriented symBOlic Language | In English | → Programming languages |
| SNV | Schweizerische Normen-Vereinigung (www.snv.ch) | In German | → Standardization → Organizations and associations |
| SNZ | Standards New Zealand | In English | → Standardization |
| SOA | Service-Oriented Architecture | In English | → Computer science |
| SOAP | Simple Object Access Protocol | In English | → Networks, communication |
| SOARS | Shuttle Operation Automated Reporting System | In English | → Knowledge management → Spaceflight engineering, astronautics |
| SOC | Simulation Operation Computer | In English | → Computer simulation |
| SOC | Service-oriented Computing | In English | → Computer-based techniques |
| SOCAR | Shuttle Operational Capability Assessment Report | In English | → Quality management → Spaceflight engineering, astronautics |
| SOCC | Shuttle Operations Computing Center | In English | → Computer science → Spaceflight engineering, astronautics |
| SOCH | Spacelab Orbiter Common Hardware | In English | → Hardware → Spaceflight engineering, astronautics |
| SODB | Start Of Data Block | In English | → Data |
| SODS | Shuttle Operational Data Submittal | In English | → Data → Spaceflight engineering, astronautics |
| SODS | Shuttle Operational Data System | In English | → Data → Spaceflight engineering, astronautics |
| SOGEP | Société Générale de Prestations | In French | → Maintenance and logistics |
| SOGITS | Senior Officials Group on Information Technology Standardization | In English | → Computer science → Standardization → Food technology |
| SOIS | Spacelab/Orbiter Interface Simulator | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SOISIC | Saisie Optique Informatique de Structures Industrielles Complexes | In French | → Computer-based techniques → Engineering, technology |
| SOLAP | Spatial On Line Analytical Processing | In English | → Knowledge management → Data |
| SOMM | Software Operations and Maintenance Manual | In English | → Software |
| SOP | Subsystem Operating Program | In English | → Software |
| SOP | Standard Operating Procedures | In English | → Management |
| SOPC | System On a Programmable Chip | In English | → Hardware → Electronics |
| SOR | Specific Operational Requirement | In English | → Management |
| SOR | Specification Operational Requirement | In English | → Management |
| SOS | Source Of Supply | In English | → Maintenance and logistics |
| SP | Stored Procedure | In English | → Software → Data |
| SPA | Signal Processor Assembly | In English | → Hardware → Electronics → Telecommunications |
| SPA | Software Product Assurance | In English | → Software |
| SPA | Simple Power Analysis | In English | → Hardware |
| SPAF | Simulation Processor and Formatter | In English | → Computer simulation |
| SPAG | Standards Promotion and Application Group | In English | → Standardization |
| SPAN | Services and Protocols for Advanced Networks | In English | → Networks, communication → Telecommunications |
| SPARC | Semantic Phonetic Automatic Reconstruction of Dictations | In English | → Computer-based techniques → Language, linguistics, literature |
| SPARQL | SPARQL Protocol And RDF Query Language | In English | → Data → Networks, communication |
| SPC | Software Productivity Consortium | In English | → Software |
| SPC | Shipping and Packing Cost | In English | → Maintenance and logistics → Prices |
| SPC | Stored Program Command | In English | → Software |
| SPC | Stored Program Control | In English | → Software |
| SPC | Starting-Point Code | In English | → Software |
| SPCR | Software Problem Change Request | In English | → Software |
| SPCS | Service and Performance Checkout System | In English | → Quality management |
| SPCU | Simulation Process Control Unit | In English | → Computer simulation |
| SPDIF | Sony-Philips Data Interchange Format | In English | → Networks, communication → Telecommunications |
| SPDR | Software Preliminary Design Review | In English | → Software |
| SPE | Software Process Engineering | In English | → Software |
| SPEARS | Supplier Performance Evaluation and Rating System | In English | → Quality management |
| SPF | Software Production Facility | In English | → Software |
| SPFA | Single-Point Failure Analysis | In English | → Quality management |
| SPFL | Single-Point Failure List | In English | → Quality management |
| SPFM | Single-Point Failure Mode | In English | → Quality management |
| SPFP | Single-Point Failure Potential | In English | → Quality management |
| SPIMS | Shuttle Program Information Management System | In English | → Knowledge management → Spaceflight engineering, astronautics |
| SPINES | Science and Technology Policy Information Exchange System | In English | → Research policy → Public administration, government → Mathematics and natural sciences → Applied sciences, technology |
| SPL | Serialized Parts List | In English | → Maintenance and logistics |
| SPL | System Programming Language | In English | → Programming languages |
| SPM | Standard Parts Manual | In English | → Maintenance and logistics |
| SPM | Software Performance Monitor | In English | → Software |
| SPM | Software Programmer's Manual | In English | → Software |
| SPM | Subsystem Project Manager | In English | → Management |
| SPO | Special Projects Office | In English | → Management |
| SPO | Spare Parts Order | In English | → Maintenance and logistics |
| SPOC | Shuttle Portable On-Board Computer | In English | → Hardware → Spaceflight engineering, astronautics |
| SPOM | STS Planning and Operations Management | In English | → Management |
| SPOM | Self Programmable One-chip Microcomputer | In English | → Hardware → Electronics → Telecommunications |
| SPP | Serial Port Profile | In English | → Hardware |
| SPPL | Spare Parts Provisioning List | In English | → Maintenance and logistics |
| SPR | Subcontractor Performance Review | In English | → Quality management → 3474 |
| SPR | Software Problem Report | In English | → Software → Quality management |
| SPRD | System Performance Requirements Document | In English | → Quality management |
| SPS | Software Productivity Solution | In English | → Software |
| SPS | Software Product Specification | In English | → Software |
| SPSC | Signal Processing and Speech Communication | In English | → Document processing → Language, linguistics, literature |
| SPT | System Planning Tool | In English | → Software |
| SPUR | Separate Parts Usage Record | In English | → Maintenance and logistics |
| SQ | Système Qualité | In French | → Quality management |
| SQA | Subcontractor Quality Assurance | In English | → Quality management → 3474 |
| SQA | Software Quality Assurance | In English | → Software → Quality management |
| SQALE | Speech recognizer Quality Assessment for Linguistic Engineering | In English | → Computer-based techniques → Linguistics |
| SQC | Statistical Quality Control | In English | → Quality management |
| SQE | Software Quality Evaluation | In English | → Software → Quality management |
| SQE | Supplier Quality Evaluation | In English | → Quality management |
| SQEP | Software Quality Evaluation Plan | In English | → Quality management |
| SQH | Supplier Quality History | In English | → Quality management |
| SQIDS | Satellite Quick-Look Interactive Display System | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SQL | Structured Query Language | In English | → Data |
| SQMS | Scottish Quality Management System | In English | → Management |
| SR&PA | Safety, Reliability, And Product Assurance | In English | → Quality management |
| SR&Q | Safety, Reliability, And Quality | In English | → Quality management |
| SR&QA | Safety, Reliability, And Quality Assurance | In English | → Quality management |
| SRAM | Static Random Access Memory | In English | → Memories |
| SRB | Software Review Board | In English | → Organizations and associations → Computer science |
|