| SSIP | System Software Interface Processing | In English | → Software → Human-computer interaction |
| SSIT | MIT's Student Services Information Technology | In English | |
| SSL | System Software Loader | In English | → Software |
| SSL | Secure Socket Layer | In English | → Networks, communication |
| SSL | Secure Sockets Layers | In English | → Networks, communication |
| SSM | Spacecraft System Monitor | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SSML | Speech Synthesis Markup Language | In English | → Programming languages → Data |
| SSMS | Summer School on Multimedia Semantics | In English | → Computer-based techniques → Semiotics |
| SSO | Single Sign-On | In English | → Software |
| SSO | Single Sign On | In English | → Networks, communication |
| SSO | Systems Software Office | In English | → Software |
| SSP | Standard Switch Panel | In English | → Software |
| SSPF | Space Shuttle Programming Facility | In English | → Software → Spaceflight engineering, astronautics |
| SSPM | Software Standards and Procedures Manual | In English | → Software |
| SSR | Software Specification Review | In English | → Software |
| SSRN | System Software Reference Number | In English | → Software |
| SSS | Spacecraft Software System | In English | → Software → Spaceflight engineering, astronautics |
| ST&E | Security Test and Evaluation | In English | → Data |
| STADAC | Station Data Acquisition And Control | In English | → Data |
| STADAN | Space Tracking And Data Acquisition Network | In English | → Data → Spaceflight engineering, astronautics |
| STADAN | Satellite Tracking And Data Acquisition Network | In English | → Data → Spaceflight engineering, astronautics |
| STADU | System Termination And Display Unit | In English | → Human-computer interaction |
| STAR | Software Tools And Requirements | In English | → Software |
| STARS | Software Technology for Adaptable and Reliable Systems | In English | → Software |
| StCom | Statistics and Computing | In English | → Serial publications, periodicals → Statistics |
| STD | Software Test Description | In English | → Software |
| STD | Secondary Transmitted Data | In English | → Data → Telecommunications |
| STDN | Spacecraft Tracking and Data Network | In English | → Data → Networks, communication → Spaceflight engineering, astronautics |
| STERIA | SociéTÉ de Réalisations en Informatique et Automatisme | In French | → Computer-based techniques → Mechanical engineering |
| STIC | Sciences des Technologies de l’Information et la Communication | In French | → Telecommunications |
| STID | Statistiques et Traitement Informatique des Données | In French | → Computer-based techniques → Statistics |
| STIL | Software Test and Integration Laboratory | In English | → Research institutes → Software |
| STIMDI | Sveriges Tvärvetenskapliga intresseförening för Människa Datorinteraktion | In Swedish | → Human-computer interaction |
| STIVE | Standard Interface Verification Equipment | In English | → Data |
| STL | Speech Transmission Laboratory | In English | → Research institutes → Computer-based techniques → Linguistics |
| STL | Sciences et Techniques du Logiciel | In French | → Software |
| STL | Standard Template Library | In English | |
| STLDD | Software Top-Level Design Document | In English | → Software |
| STN | Software Trouble Note | In English | → Software |
| sTN | Stichting Telecom- en internetgebruikers Nederland | In Dutch | → Foundations → Networks, communication → Telecommunications |
| STOICAL | STack Oriented Interactive Compiler Adapted to Linux | In English | → Software → Operating systems |
| STP | Software Test Procedure | In English | → Software |
| STP | Software Test Plan | In English | → Software |
| STP | Software Technology Program | In English | → Software |
| STQ | Speech Processing, Transmission and Quality Aspects | In English | → Computer-based techniques → Telecommunications |
| STR | Software Test Report | In English | → Software |
| STR | Stratégie en Temps Réél = RTS | Real-Time Strategy | In English |
In French | → Entertainment |
| STRI | Systèmes de Télécommunications et Réseaux Informatiques | In French | → Telecommunications |
| STSI | Service des Technologies et de la Société de l’Information | In French | → Telecommunications |
| SUBP | Sustav za upravljanje bazom podataka = DBMS | Data Base Management System | In English = SGBD | Système de Gestion de Base de Données | In French = SŘBD | Systém řízení báze dat | In Czech = SGBD | Sistema de Gestió de Bases de Dades | In Catalan = SMBD | Sistem manajemen basis data | In Indonesian = DBKS | Datu-baseak kudeatzeko sistema | In Basque = SGBD | Sistema de gestión de base de datos | In Spanish = DBMS | Datenbankmanagementsystem | In German |
In Croatian | → Data |
| SUL | Software Utilization List | In English | → Software |
| SUM | Software User's Manual | In English | → Software |
| SUMC | Space Ultrareliable Modular Computer | In English | → Hardware → Spaceflight engineering, astronautics |
| SUN | Stanford University Network | In French | → Networks, communication |
| SUSHI | Standardized Usage Statistics Harvesting Initiative | In English | → Libraries |
| SVCDS | Space Vehicle Computer Design System | In English | → Hardware → Spaceflight engineering, astronautics |
| SVCDS | Space Vehicle Control/Display Simulation | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SVG | Scalable Vector Graphics | In English | → Programming languages → Data → Graphical processing |
| SVIA | Schweizerischer Verein für Informatik in der Ausbildung = SSIE | Société Suisse pour l'Informatique dans l'Enseignement | In French = SSII | Società Svizzera per l'Informatica nell'Insegnamento | In Italian |
In German | → Organizations and associations → Education |
| SVICP | Shock Vibration Information Center - Shock Vibration Computer Programs | In English | → Serial publications, periodicals → Software → Acoustics |
| SVM | Support Vector Machine | In French | → Mathematics |
| SVM | Star View Metafile | In French | → Document processing |
| SVP | Software Verification Procedure | In English | → Software |
| SVRR | Software Verification Readiness Review | In English | → Software |
| SW | Software | In English | → Software |
| SWAD | Semantic Web Advanced Development | In English | → Internet → Computer-based techniques → Semiotics |
| SWCC | Southwestern Computing Center | In English | |
| SWCDR | Software Critical Design Review | In English | → Software |
| SWCI | Software Configuration Inspection | In English | → Software |
| SWD&I | Software Development and Integration | In English | → Software |
| SWEE | Software Engineering Environment | In English | → Software |
| SWG | Software Working Group | In English | → Software |
| SWPDR | Software Preliminary Design Review | In English | → Software |
| SWRR | Software Readiness Review | In English | → Software |
| SWS | Software System | In English | → Software |
| SWS | Semantic Web School | In English | → Computer-based techniques → Telecommunications → Semiotics |
| SWSF | Semantic Web Science Foundation | In English | → Foundations → Software → Networks, communication → Language, linguistics, literature |
| SWSW | Semantic Web Services Week | In English | → Internet → Computer-based techniques → Semiotics |
| SWWG | Software Working Group | In English | → Software |
| TAIM | Traitement Automatique de l'Information Multimédia | In French | → Computer-based techniques |
| TALN | Traitement Automatique du Langage Naturel | In French | → Computer-based techniques → Linguistics |
| TALNE | Traitement Automatique du Langage Naturel Écrit | In French | → Computer-based techniques → Linguistics |
| TALNEO | Traitement Automatique de la Langue Naturelle Écrite et Orale | In French | → Computer-based techniques → Linguistics |
| TALNO | Traitement Automatique du Langage Naturel Oral | In French | → Computer-based techniques → Linguistics |
| TAVERNS | Test And Verification Environment for Remotely Networked Systems | In English | → Networks, communication |
| TCAO | Traitement de Corpus Assisté par Ordinateur | In French | → Computer-based techniques → Language, linguistics, literature |
| TCM | Total Content Management | In English | → Document processing → Knowledge management |
| TCP | Transmission Control Protocol | In English | → Internet |
| TCP/IP | Transmission Control Protocol/Internet Protocol | In English | → Internet |
| TCSC | Trainer Control and Simulation Computer | In English | → Hardware |
| TDAPR | Telecommunications and Data Acquisition Progress Report | In English | → Serial publications, periodicals → Data → Telecommunications |
| TDMS | Terminal Data Management System | In English | → Data |
| TDP | Tracking Data Processor | In English | → Hardware → Data |
| TDSP | Time-Dependent Signal Processor | In English | → Hardware |
| TEI | Text Encoding Initiative | In English | → Data |
| TelIn | Telematics Informatics | In English | → Serial publications, periodicals → Telecommunications |
| TES | Transactions Électroniques Sécurisées | In French | → Networks, communication → Electronics → Telecommunications |
| THAP | Thermal/Hydraulic Analyzer Digital Computer Program | In English | → Software |
| TI | Tecnoloxías da información = IT | Information Technology | In English = IT | Informationstechnik | In German = IT | Inligtingstegnologie | In Afrikaans = TI | Tecnologia da Informação | In Portuguese |
In Galician | → Telecommunications |
| TI | Tecnologia da Informação = IT (look above) |
In Portuguese | → Telecommunications |
| TIA | Terminologie et Intelligence Artificielle | In French | → Computer-based techniques → Linguistics |
| TIC | Technologies de l'Information et de la Communication = TIC | Tecnologías de la Información y la Comunicación | In Spanish = IKT | Informations- und Kommunikationstechnologie | In German = ICT | Information and Communications Technology | In English = IKT | Informations- og kommunikationsteknologi | In Danish = IKT | Inligtings- en kommunikasietegnologie | In Afrikaans = ICT | Informatie- en Communicatietechnologie | In Dutch = TMK | Teknologi Maklumat dan Komunikasi | In Malay |
In French | → Telecommunications |
| TIC | Tecnologías de la Información y la Comunicación = IKT, ICT, TMK (look above) |
In Spanish | → Telecommunications |
| TID | Telefónica Investigación y Desarrollo | In Spanish | → Networks, communication → Telecommunications |
| TIFF | Tagged Image File Format | In English | |
| TISI | Technologies de l’Information appliquées aux Systèmes Industriels | In French | → Computer-based techniques → Engineering, technology |
| TIWG | Technical Interface Working Group | In English | → Human-computer interaction |
| TLCSC | Top-Level Computer Software Component | In English | → Software |
| TLD | Top Level Domain | In English | → Networks, communication → Telecommunications |
| TLS | Transport Layer Security | In English | → Networks, communication |
| TMA | Tierce Maintenance Applicative | In French | → Software |
| TMK | Teknologi Maklumat dan Komunikasi = TIC, IKT, ICT (look above) |
In Malay | → Telecommunications |
| TNS | Transaction Network Services (www.tnsi.com) | In English | → Networks, communication → Telecommunications |
| TNS | Total Network Solutions (www.tns.co.uk) | In English | → Hardware → 6218 → Telecommunications |
| TOCR | Transym Optical Character Recognition | In English | → Writing systems → Document processing |
| TOMS | Transactions on Mathematical Software | In English | → Serial publications, periodicals → Software → Mathematics |
| TOS | Type Of Service | In English | → Networks, communication |
| TÖTIAD | Türk(iye) Örüntü Tanıma ve İmge Anlama Derneği | In Turkish | → Organizations and associations → Graphical processing → Image processing |
| TPC | Telemetry Preprocessor Computer | In English | → Hardware |
| TPMs | Technological Protection Measures | In English | → Software → Artistic property |
| TPO | Towarzystwo Przetwarzania Obrazów | In Polish | → Organizations and associations → Image processing |
| TrAX | Transformation API for XML | In English | → Software → Data |
| TREND | Technical Requirements Engineering Network Data Base | In English | → Data |
| TROLL | Troupe Redonnaise Orientée Logiciel Libre | In French | → Software → Operating systems |
| TROPICS | TRansformations et Outils Informatiques Pour le Calcul Scientifique | In French | → Mathematics |
| TSCS | Test Support Computer System | In English | → Hardware |
| TSIS | Traffic Software Integrated System | In English | → Software → Transport and postal services |
| TSP | Trajectory Synthesis Program | In English | → Software → Spaceflight engineering, astronautics |
| TSP | Trajectory Shaping Program | In English | → Software → Spaceflight engineering, astronautics |
| TSP | Test Software Program | In English | → Software |
| TSS | Test Software Support | In English | → Software |
| TSW | Test Software | In English | → Software |
| TTCN | Tree and Tabular Combined Notation | In English | → Programming languages → Networks, communication |
| TTI | Translation Technologies, Inc. (www.translationtech.com) | In English | → Computer-based techniques → Linguistics |
| TTT | Tut-Tera Teksaĵo = WWW | World Wide Web | In English |
In Esperanto | → Internet |
| TÜBİSAD | Türkiye Bilgi İşlem Hizmetleri Derneği (www.tubisad.org.tr) | In Turkish | → Associations |
| U&E | Usability & Ergonomie | In English | → Human-computer interaction |
| UAM | User Authentification Module | In English | → Software |
| UAM | Unité d'Appui Multimédia | In French | → Document processing |
| UBE | Uluslararası Bilgisayar Enstitüsü | In Turkish | → Higher education, universities |
| UBER | Undetected Bit Error Rate | In English | |
| UCC | Universal Checkout Console | In English | → Hardware → Human-computer interaction |
| UCE | Unsolicited Commercial Email | In English | → Networks, communication → Telecommunications |
| UCS | Universal Character Set | In English | → Writing systems → Data |
| UDDI | Universal Description Discovery and Integration | In English | → Networks, communication → Telecommunications |
| UDP | User Datagram Protocol | In English | → Networks, communication |
| UDWDM | Ultra Dense Wavelength Division Multiplexing | In English | → Networks, communication → Telecommunications |
| UFD | User File Directory | In English | → Software |
| UFM | Utilisateurs Francophones de Medidoc/Clinidoc | In French | → Organizations and associations → Medicine |
| UGC | User Generated Content | In English | → Networks, communication → Computer-based techniques |
| UI | User Interface | In English | → Human-computer interaction |
| UIML | User Interface Markup Language | In English | → Programming languages → Human-computer interaction |
| UIMS | User Interface Management System | In English | → Human-computer interaction |
| UIR | Universal Infrared Receiver | In English | |
| UIUC DLI | University of Illinois at Urbana-Champaign Digital Library Initiative | In English | → Libraries → Data |
| UIWG | User Interface Working Group | In English | → Human-computer interaction |
| UML | Unified Modeling Language | In English | → Management |
| UNE | Unbundled Network Elements | In English | → Networks, communication → Telecommunications |
| UPA | Usability Professionals' Association | In English | → Associations → Human-computer interaction |
| UPF | Universal Patch Format | In English | → Software |
| UPP | User Parameter Processor | In English | → Hardware |
| URI | Uniform Resource Identifier | In English | → Libraries → Networks, communication |
| URL | Uniform Resource Locator | In English | → Networks, communication |
| USA2D/3D | Unified Solutions Algorithm 2-Dimensional/3-Dimensional | In English | |
| USI | Update Software Identity | In English | → Software |
| USI | User System Interface | In English | → Human-computer interaction |
| UTRAN | UMTS Terrestrial Radio Access Network | In English | → Networks, communication → Telecommunications |
| UVPE | UV/Video Processing Electronics | In English | → Image processing → Electronics |
| V&DA | Video and Data Assembly | In English | → Data → Image processing |
| V&DA | Video and Data Acquisition | In English | → Data → Image processing |
| VADC | Venting Analysis Digital Computer | In English | → Hardware |
| VAX | Virtual Address Extended | In English | → Networks, communication |
| VBC | Video Bandwidth Compressor | In English | → Telecommunications |
| VC-ATOD | Virtual Clearinghouse on Alcohol, Tobacco, and Other Drugs = CV-ATOD | Centro Virtual de Información sobre Alcohol, Tabaco y otras Drogas | In Spanish |
In English | → Networks, communication → Medicine |
| VCP | Vehicle Control Processor | In English | → Hardware → Vehicle engineering |
| VDA | Video Data Assembly | In English | → Data → Image processing |
| VDA | Variable Data Area | In English | → Data |
| VDB | Verification Data Base | In English | → Data |
| VDD | Visual Display Data | In English | → Human-computer interaction |
| VDE | Visual Display Equipment | In English | → Human-computer interaction |
| VDF | Validation Data File | In English | → Data |
| VDI | Vector Display Indicator | In English | → Human-computer interaction |
| VDI | Virtual Desktop Infrastructure | In English | → Software |
| VDS | Visual Display System | In English | → Human-computer interaction |
| VDSL | Very High Speed Digital Subscriber Line | In English | → Networks, communication |
| VDU | Visual Display Unit | In English | → Human-computer interaction |
| VEB | Virtuala Esperanto-Biblioteko | In Esperanto | → Internet → Libraries |
| VECAM | Veille européenne et citoyenne sur les autoroutes de l'information et le multimédia | In French | → Telecommunications |
| VEKI | Virtuala Esperanto Kongreso Internacia | In Esperanto | → Networks, communication |
| VHDSL | Very High Speed Digital Subscriber Line | In English | → Networks, communication |
| VI | Vještačka inteligencija = AI | Artificial Intelligence | In English = AI | Artificiële Intelligentie | In Dutch = KI | Kunstmatige Intelligentie | In Dutch = IA | Intelligència artificial | In Catalan = KI | Künstliche Intelligenz | In German = AI | Artefarita Inteligenteco | In Esperanto = IA | Intelligence Artificielle | In French |
In Bosnian | → Artificial intelligence |
| VIEW | Visual Interactive Effective Worlds | In English | → Graphical processing → Image processing |
| VIP | Virtual Instance Port | In English | → Networks, communication → Telecommunications |
| VITE | Vienna IT Enterprises | In English | → Networks, communication → Telecommunications |
| VIU | Video Interface Unit | In English | → Human-computer interaction |
| VIU | Vehicle Interface Unit | In English | → Human-computer interaction → Vehicle engineering |
| VLK | Volume License Key | In English | → Software |
| VM | Virtual Memory | In English | → Memories → Software |
| VMC | United States Computer Emergency Readiness Team | In English | |
| VML | Vector Markup Language | In English | → Programming languages → Image processing |