| MDB | Master Data Base | In English | → Data |
| MDC | Main Display Console | In English | → Human-computer interaction |
| MDC | Mozilla Developer Center | In English | → Software → Networks, communication |
| MDCS | Material Data Collection System | In English | → Data → 620 |
| MDCS | Master Digital Command System | In English | → Human-computer interaction |
| MDDS | Material Directory Data Sheet | In English | → Data → 620 |
| MDI | Människa-datorinteraktion = MMI | Man-Machine Interaction | In English = CHI | Computer-Human Interaction | In English = IHM | Interface Homme-Machine | In French |
In Swedish | → Human-computer interaction |
| MDL | Master Data Library | In English | → Libraries → Data |
| MDP | Master Display Panel | In English | → Human-computer interaction |
| MDP | Main Display Panel | In English | → Human-computer interaction |
| MDS | Magnetic Disk System | In English | → Hardware |
| MDS | Mission Development Simulator | In English | → Computer simulation |
| MDSD | Model Driven Software Development | In English | → Software |
| MECA | Missile Electronics Computer Assembly | In English | → Electronics → Military engineering |
| MECF | Main Engine Computational Facilities | In English | → Vehicle engineering |
| MEDICS | Medical Information Computer System | In English | → Medicine |
| MEECN | Minimum Essential Emergency Communication Network | In English | → Networks, communication → Telecommunications |
| MEL | Maya Embedded Language | In English | → Graphical processing → Image processing → Cinema, movies |
| MELROSE | Mitsubishi Electric Road Traffic Simulation Environment | In English | → Computer simulation → Transport and postal services |
| MESCAL | Middleware Efficiently SCALable | In English | → Software → Networks, communication |
| MESH | Multimedia Semantic Syndication for Enhanced News Services (www.mesh-ip.eu) | In English | → Computer-based techniques → Telecommunications |
| MetPetDB | Metamorphic Petrology Database | In English | → Data → Petrology |
| MFC | Multiple-Flight Computer | In English | → Hardware → Aeronautics, aircraft → Spaceflight engineering, astronautics |
| MFC | Mel Frequency Cepstral | In English | → Computer-based techniques → Linguistics |
| MFCC | Mel Frequency Cepstrum Coefficients | In English | → Computer-based techniques → Linguistics |
| MFLOPS | Millions Of Floating-Point Operations Per Second | In English | |
| MHEG | Multimedia and Hypermedia Experts Group | In English | → Newspapers, journalism |
| MHS | Message Handling System | In English | → Computer-based techniques |
| MIA | Multiplexer Interface Adapter | In English | → Human-computer interaction |
| MIA | Multiple-Interface Adapter | In English | → Human-computer interaction |
| MIAGE | Méthodes Informatiques Appliquées à la Gestion | In French | → Computer-based techniques → Economics |
| MIAM | Mathématiques Internet Aix Marseille | In French | → Networks, communication → Mathematics |
| MIAS | Mathématiques, Informatique et Application aux Sciences | In French | → Mathematics and natural sciences → Mathematics |
| MIASHS | Mathématiques et Informatique Appliquées aux Sciences Humaines et Sociales | In French | → Social sciences → Mathematics |
| MIAU | Multiple Internet Agents for User-adaptive Decision | In English | → Networks, communication → Telecommunications |
| MIB | Minimum-Impulse Bit | In English | |
| MIC | Management Information Center | In English | |
| MIC | Memory Interface Connector | In English | → Memories |
| MICSTRAN | Microscopic Simulator Model for Traffic Networks | In English | → Computer simulation → Transport and postal services |
| MIDDS | Meteorological Interactive Data Display System | In English | → Human-computer interaction → Meteorology, climatology |
| MIDP | Mobile Information Device Profile | In English | |
| MIME | Multipurpose Internet Mail Extensions | In English | → Internet |
| MIME | Multipurpose Internet Mail Extensions | In English | → Internet |
| MIME | Multipupose Internet Mail Extension | In English | → Networks, communication |
| MIMO | Multiple-Input Multiple-Output | In English | |
| MIMOSA | Migration et Mobilité - Sémantique et Applications | In French | → Computer-based techniques → Telecommunications → Semiotics |
| MINC | Multilingual Internet Names Consortium | In English | → Internet |
| MINW | Master Interface Network | In English | → Human-computer interaction → Networks, communication |
| MISASHS | Mathématiques, Informatique et Statistiques Appliquées aux Sciences Humaines et Sociales | In French | → Social sciences → Statistics → Mathematics |
| MITACS | Mathematics of Information Technology and Complex systems | In English | → Mathematics |
| MITSIM | Microscopic Traffic Simulator | In English | → Computer simulation → Transport and postal services |
| MITSIS | Massachussets Institute of Technology's Student Information System | In English | → Knowledge management → Specialized or (poly)technical colleges |
| MLC | Mobile Launcher Computer | In English | → Hardware → Spaceflight engineering, astronautics |
| MLE | Maximum Likelihood Estimation | In French | → Mathematics |
| MLear | Machine Learning | In English | → Serial publications, periodicals → Artificial intelligence |
| MLP | Machine Language Program | In English | → Programming languages |
| MLUG | Montreal Linux Users Group | In English | → Organizations and associations → Operating systems |
| MM | Main Memory | In English | → Memories |
| MMC | Master Microprocessor Control | In English | → Hardware → Electronics |
| MMDB | Master Measurement Data Base | In English | → Data |
| MMDF | Mission Model Data File | In English | → Data |
| MMDS | Maintenance Management Data System | In English | → Data → Maintenance and logistics |
| MMES | Mikroszámítógép-mikroelektronikai értelmező szótár | In Hungarian | → Dictionaries |
| MMI | Man-Machine Interface | In English | → Human-computer interaction |
| MMI | Man-Machine Interaction = MDI, CHI, IHM (look above) |
In English | → Human-computer interaction |
| MMIDS | Man-Machine Interface Development Station | In English | → Human-computer interaction |
| MMIE | Maximum Mutual Information Estimation | In English | → Linguistics |
| MMIP | Mass Memory Integration Plan | In English | → Memories |
| MMO | Massively Multiplayer Online | In English | → Software → Networks, communication |
| MMORPG | Massively Multiplayer Online Role Playing Game | In English | → Software |
| MMT | Mass Memory Test | In English | → Memories |
| MMT | Médecins Maîtres-Toile | In French | → Networks, communication → Organizations and associations → Medicine |
| MMU | Mass Memory Unit | In English | → Memories |
| MMUS | Mass Memory Unit Simulator | In English | → Memories |
| MN | Main Bus | In English | |
| MOC | Mission Operations Computer | In English | → Hardware |
| MOCF | Mission Operations Computational Facility | In English | |
| MOCN | Machine-Outil à Commande Numérique | In French | → Computer-based techniques → Mechanical engineering |
| MOLAP | Multidimensional On Line Analytical Processing | In English | → Knowledge management → Data |
| MOM | MiddleWare Orienté Message | In French | |
| MOM | Message Oriented Middleware | In English | → Software |
| MOP | Mission Operations Processor | In English | → Hardware |
| MOSS | Microsoft Office SharePoint Server | In English | → Networks, communication → Knowledge management |
| MPC | Memory Protection Check | In English | → Memories |
| MPEG | Moving Picture Experts Group | In English | → Graphical processing → Image processing → Cinema, movies |
| MPI | Message Passing Interface | In English | → Human-computer interaction |
| MPI | Message Parsing Interface | In English | → Human-computer interaction |
| MPII | Max-Planck-Institut Informatik | In German | |
| MPL | Master Program Library | In English | → Software |
| MPLS | Multi Protocol Label Switching | In English | → Networks, communication → Food technology |
| MRAM | Magnetoresistive Random Access Memory | In English | → Memories |
| MRAM | Magnetic Random Access Memory | In English | → Memories |
| MRBT | Maintenance Réseaux-Bureautique-Télématique | In French | → Telecommunications |
| MRDR | Material Review Disposition Record | In English | → Image processing |
| MRI | Mixed Reality Interface | In English | → Human-computer interaction |
| MRIM | MOD/MOC Reconfiguration Interface Manager | In English | → Human-computer interaction |
| MRLUG | Montreal Regional Linux Users Group | In English | → Organizations and associations → Operating systems |
| MRO | Memory Read-Out | In English | → Memories |
| MRZ | Medizinisches Rechenzentrum | In German | → Medicine |
| MS-DOS | Microsoft Disk Operating System | In English | → Operating systems |
| MSB | Most Significant Bit | In English | |
| MSDNAA | Microsoft Developer Network Academic Alliance | In English | → Organizations and associations |
| MSDOS | Microsoft Disk Operating System | In English | → Operating systems |
| MSDOS | Mass Storage Digital Operating System | In English | → Operating systems |
| MSDT | Multiple Shuttle Data Tape | In English | → Data → Spaceflight engineering, astronautics |
| MSIS | Man-Systems Integration Standards | In English | → Standardization → Human-computer interaction |
| MSK | Manual Select Keyboard | In English | → Hardware |
| MSK | Mary Shift Keying | In English | → Human-computer interaction |
| MSKLC | Microsoft Keyboard Layout Creator | In English | → Operating systems |
| MSL | Master System Library | In English | |
| MSS | Multisystem Software | In English | → Software |
| MTBF | Mean Time Between Failure | In English | |
| MTC | Microsoft Technology Center | In English | |
| MTG | Music Technology Group | In English | → Computer-based techniques → Music |
| MTJ | Mobile Tools for Java | In English | → Software |
| mTLD | mobile Top Level Domain | In English | → Networks, communication → Telecommunications |
| MTM | Multiterminal Monitor | In English | → Human-computer interaction |
| MUMPS | Massachusetts General Hospital Utility Multi-Programming System | In English | → Programming languages → Medicine |
| MUNCI | Mouvement pour une Union Nationale des Consultants en Informatique | In French | → Organizations and associations → 6592 |
| MUS | Mission-Unique Software | In English | → Software |
| MUSIC | Multiple Signal Classification | In English | → Networks, communication → Telecommunications |
| MVD | Map and Visual Display | In English | → Human-computer interaction |
| MVS | Multiple Virtual Storage | In English | → Memories |
| MXML | Macromedia Flex Markup Language | In English | → Programming languages |
| NA | Network Aspects | In English | → Networks, communication |
| NAD | Network Adapter Device | In English | → Hardware → Networks, communication |
| NAOMI | North American OpenMath Initiative | In English | → Mathematics |
| NAPCTC | North American Policy Council for OSI (Open Systems Interconnection) Testing and Certification | In English | |
| NAR | Numerical Analysis Research | In English | → Computer-based techniques |
| NAS | Nonavionics Simulator | In English | → Computer simulation → Aeronautics, aircraft |
| NAS | Network Attached Storage | In English | → Networks, communication → Knowledge management |
| NAS | Numerical Aerodynamic Simulation | In English | → Computer simulation → Aerodynamics |
| NAUTILE | Noyau d'Aide à l'Usage, la Transmission et l'Installation des Logiciels libres sur l'Estuaire | In French | → Organizations and associations → Software |
| NBIC | Nanotechnology, Biotechnology, Information Technology and Cognitive Science | In English | → Biotechnology → Engineering, technology |
| NBMA | Nonbroadcast Multiple Access Network | In English | → Networks, communication → Telecommunications |
| NCC | Network Control Center | In English | → Networks, communication |
| NCIU | Network Common Interface Unit | In English | → Human-computer interaction → Networks, communication |
| NCM | National Cryptologic Museum (www.nsa.gov/museum/) | In English | → Museums → Mathematics |
| NCM | Network Connection Manager | In English | → Software → Networks, communication |
| NCNS | Network: Computation in Neural Systems | In English | → Serial publications, periodicals → Artificial intelligence |
| NCS | Network Control Station | In English | → Networks, communication |
| NCSA | National Center for Supercomputing Applications | In English | |
| NCSC | National Computer Security Center | In English | |
| NDS | Network Distribution Service | In English | → Networks, communication |
| NeCom | Neural Computation | In English | → Serial publications, periodicals → Computer-based techniques |
| NEEDS | NASA End-To-End Data System | In English | → Data → Astronomy → Spaceflight engineering, astronautics |
| NEPOMUK | Networked Environment for Personalized, Ontology-based Management of Unified Knowledge | In English | → Software → Knowledge management |
| NES | Network Encryption System | In English | → Networks, communication → Mathematics |
| NETSIM | Network Simulation | In English | → Computer simulation |
| NFS | Network File Server | In English | → Hardware → Networks, communication |
| NIDS | Network Interface Data System | In English | → Human-computer interaction → Networks, communication |
| NIDS | Network Intrusion Detection System | In English | |
| NIP | Network Input Processor | In English | → Hardware → Networks, communication |
| NIP | Network Interface Processor | In English | → Hardware → Human-computer interaction → Networks, communication |
| NIU | Network Interface Unit | In English | → Human-computer interaction → Networks, communication |
| NJP | Network Job Processing | In English | → Networks, communication |
| NLP | Natural Language Processing | In English | → Computer-based techniques → Linguistics |
| NLU | Natural Language Understanding | In English | → Artificial intelligence → Computer-based techniques |
| NMF | Network Management Forum | In English | → Organizations and associations → Networks, communication |
| NN | Neural Networks | In English | → Serial publications, periodicals → Computer-based techniques → Neurology |
| NNTP | Network News Transport Protocol | In English | → Networks, communication |
| NOM | Network Output Multiplexer | In English | → Networks, communication |
| NOS | Network Operating System | In English | → Hardware → Networks, communication |
| NREN | National Research and Education Network | In English | → Networks, communication → Research policy → Education |
| NSC | NASA Standard Computer | In English | → Hardware → Spaceflight engineering, astronautics |
| NSI | NASA Science Internet | In English | → Internet → Spaceflight engineering, astronautics → Astronomy |
| NSP | Network Signal Processing | In English | → Hardware → Networks, communication |
| NSP | Network Signal Processor | In English | → Hardware → Networks, communication |
| NSS | Network Simulation System | In English | → Networks, communication → Computer simulation |
| NSSCC | NORAD Space Surveillance Computation Center | In English | → Astronomy |
| NTDS | Naval Tactical Data System | In English | → 359 |
| NUA | Network User Address | In English | → Networks, communication |
| NuMat | Numerische Mathematik | In English | → Serial publications, periodicals → Computer-based techniques → Mathematics |
| NUMDAM | NUMérisation de Documents Anciens Mathématiques | In French | → Document processing → Libraries → Mathematics |
| NURBS | Non-Uniform Rational B-splines | In English | → Graphical processing → Image processing → Cinema, movies |
| NVM | Nonvolatile Memory | In English | → Memories |
| NVN | Netwerk van netwerken | In Dutch | → Networks, communication |
| NVPHBV | Nederlandse Vereniging voor Patroonherkenning en Beeldverwerking | In Dutch | → Organizations and associations → Graphical processing → Image processing |
| NYCCS | New York Center for Computational Science | In English | → 5196 |
| OASCB | Orbiter Avionics Software Control Board | In English | → Software → Aeronautics, aircraft → Spaceflight engineering, astronautics |
| OASIS | Orbit Avionics Software Integration Study | In English | → Software → Aeronautics, aircraft |
| OASIS | Organisation for the Advancement of Structural Information Standard | In English | → Organizations and associations → Standardization → Data → Networks, communication |
| OASIS | Objets Actifs, Sémantique, Internet et Sécurité | In French | → Networks, communication → Semiotics |
| OBC | On-Board Computer | In English | → Hardware |
| OBCP | On-Board Computer Program | In English | → Software |
| OCA | Oracle Certifiate Associate | In English | → Software → Data |
| OCA | Open Content Alliance | In English | → Organizations and associations |
| OCCP | Orbit Command Computer Program | In English | → Software → Spaceflight engineering, astronautics |
| OCF | Orbiter Computational Facilities | In English | → Spaceflight engineering, astronautics |
| OCF | On-Board Computational Facility | In English | |
| ÖCG | Österreichische Computer Gesellschaft (www.ocg.at) | In German | → Organizations and associations |
| OCH | Orbiter Common Hardware | In English | → Hardware → Spaceflight engineering, astronautics |
| OCLC | Online Computer Library Center | In English | → Libraries → Networks, communication |
| OCM | Oracle Certified Master | In English | → Software → Data |
| OCML | Operational Conceptual Modelling Language | In English | → Programming languages |
| OCP | Oracle Certified Professional | In English | → Software → Data |
| OCR | Optical Character Reader | In English | → Writing systems → Computer-based techniques |
| ODA | Open Document Architecture | In English | |
| ODB | Operational Data Base | In English | → Data |
| ODBC | Open Data Base Connectivity | In English | → Data |