| SE | Software Engineering | In English | → Software |
| SE | Système d'Exploitation | In French | → Operating systems |
| SEAL | Software-Optimized Encryption Algorithm | In English | → Software → Mathematics |
| SEAL | Semantics-directed Environment Adaptation Language | In English | → Programming languages |
| SEAL | Software Engineering and Ada Lab(oratory) | In English | → Research institutes → Software |
| SeCIU | Servicio Central de Informática Universitario | In Spanish | → Higher education, universities |
| SEE | Software Engineering Exercise | In English | → Software |
| SEE | Software Equality Evaluation | In English | → Software |
| SEEL | Syndicat des Éditeurs de Logiciels de Loisirs | In French | → Organizations and associations → Software |
| SEG | Simulation Engineering Group | In English | → Computer simulation → Engineering, technology |
| SEI | Software Engineering Institute | In English | → Software |
| SEKT | Semantic Knowledge Technologies | In English | → Computer-based techniques → Semiotics |
| SELL | Syndicat des Éditeurs de Logiciel de Loisirs (www.sell.fr) | In French | → Organizations and associations → Software → Entertainment |
| SELL | Syndicat des Éditeurs de Logiciel de Loisir (www.sell.fr) | In French | → Organizations and associations → Software → Entertainment |
| SEM | SEmantic Memory | In English | → Software → Semiotics |
| SEMA | Search Engine Marketing Association | In French | → Associations → Internet → 659 |
| SEMPO | Search Engine Marketing Professional Organization | In English | → Organizations and associations → Internet |
| SEO | Search Engine Optimization | In English | → Internet → 659 |
| SEQUEL | Structured English Query Language | In English | → Data |
| SERPs | Search Engine Ranking Pages | In English | → Internet → Computer-based techniques |
| SES | Software Evaluation Subpanel | In English | → Software |
| SESAME | Système d'Exploration de Séquences Audiovisuelles et Multimédias Enrichi par l'Expérience | In French | → Computer-based techniques → Cinema, movies |
| SET | Secure Electronic Transaction | In English | → Networks, communication → Telecommunications |
| SEVN | Syndicat de l’Édition Vidéo Numérique | In French | → Organizations and associations → Computer-based techniques → Telecommunications |
| SEXI | String EXpression Interpreter | In English | → Programming languages |
| SFACI | Software Flight Article Configuration Inspection | In English | → Software → Aeronautics, aircraft → Spaceflight engineering, astronautics |
| SFLC | Software Freedom Law Center | In English | → Software → Law, jurisprudence |
| SGAICO | Swiss Group for Artificial Intelligence and Cognitive Science | In English | → Artificial intelligence |
| SGBD | Sistema de Gestió de Bases de Dades = DBMS | Data Base Management System | In English = SGBD | Système de Gestion de Base de Données | In French = SŘBD | Systém řízení báze dat | In Czech = SMBD | Sistem manajemen basis data | In Indonesian = SUBP | Sustav za upravljanje bazom podataka | In Croatian = DBKS | Datu-baseak kudeatzeko sistema | In Basque = SGBD | Sistema de gestión de base de datos | In Spanish = DBMS | Datenbankmanagementsystem | In German |
In Catalan | → Data |
| SGBD | Système de Gestion de Base de Données = DBMS, SŘBD, SMBD, SUBP, DBKS (look above) |
In French | → Data |
| SGBD | Sistema de gestión de base de datos = DBMS, SŘBD, SMBD, SUBP, DBKS (look above) |
In Spanish | → Data |
| SGBDRO | Système de Gestion de Base de Données Relationnelle et Objet | In French | → Data |
| SGC | Système de Gestion de Contenu(s) = CMS | Content Management System | In English |
In French | → Document processing → Knowledge management |
| SGC | Server Gated Cryptography | In English | → Internet → Mathematics |
| SGDT | Système de Gestion de Données Techniques | In French | → Data → Knowledge management |
| SGML | Standard Generalized Markup Language | In English | → Programming languages → Data → Document processing |
| SHA | Secure Hash Algorithm | In English | → Mathematics |
| SHIVA | Simulated Highways for Intelligent Vehicle Algorithms | In English | → Computer simulation → Transport and postal services |
| SHLB | Simulation Hardware Load Box | In English | → Hardware → Computer simulation |
| SHOE | Simple Hypertext Ontology Extensions | In English | → Networks, communication → Linguistics |
| SHS | Simulation Hardware System | In English | → Hardware → Computer simulation |
| SI/FS | System Integration and Flight Software | In English | → Software → Aeronautics, aircraft → Spaceflight engineering, astronautics |
| SIA | Software Impact Assessment | In English | → Software |
| SIB | Simulation Interface Buffer | In English | → Human-computer interaction → Computer simulation |
| SID | Simulator Interface Device | In English | → Human-computer interaction |
| SID | Standard Interface Document | In English | → Human-computer interaction |
| SID | System Interface Document | In English | → Human-computer interaction |
| SIE | Shuttle Interface Equipment | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SIF | Service Informatique Fédéral | In French | → Central administration |
| SIG | Sistema de informação geográfica = GIS | Geographic(al) Information System | In English = SIG | Sistema Informativo Geografico | In Italian = SIG | Sistema de Información Geográfica | In Spanish = SIG | Sistema d'informació geogràfica | In Catalan = GIS | Geografický Informační Systém | In Czech = ГИС | Географска информационна система | In Bulgarian = ΓΣΠ | Γεωγραφικά Συστήματα Πληροφοριών | In Greek = GIS | Geographisches Informationssystem | In German = GIS | Geoinformationssystem | In German = GIS | Geoinfosüsteem | In Estonian = GIS | Geografski informacijski sustav | In Croatian = ממ"ג | מערכת מידע גאוגרפית | In Hebrew = GIS | Geografinė informacinė sistema | In Lithuanian = SIG | Sistem Informasi Geografis | In Indonesian = GIS | Geografisch Informatiesysteem | In Dutch = GIS | Geografiske informasjonssystem | In Nynorsk = GIS | Geografiske informasjonssystemer | In Norwegian = ГИС | Географическая Информационная Система | In Russian = GIS | Geografski informacijski sistem | In Slovenian = GIS | Geografiskt InformationsSystem | In Swedish = ГІС | Геоінформаційна система | In Ukrainian |
In Portuguese | → Software → Geography |
| SIG | Sistema de Información Geográfica = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Spanish | → Software → Geography |
| SIG | Sistema d'informació geogràfica = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Catalan | → Software → Geography |
| SIG | Sistem Informasi Geografis = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Indonesian | → Software → Geography |
| SIG | Système d'Information Géographique = TAC | Traitement Communautaire Assertif | In French = PACT | Program Assertif Community Treatment | In English |
In French | → Software → Geography |
| SIG | Sistema Informativo Geografico = GIS, ГИС, ΓΣΠ, ממ"ג, ГІС (look above) |
In Italian | → Software → Geography |
| SIGB | Système Intégré de Gestion de Bibliothèque = ILS | Integrated Library System | In English = АБИС | Автоматизированные библиотечные информационные системы | In Russian |
In French | → Knowledge management → Libraries → Software |
| SIGCHI | Special Interest Group on Computer–Human Interaction | In English | → Organizations and associations → Human-computer interaction |
| SIMAC | Semantic Interaction with Music Audio Contents | In English | → Computer-based techniques → Music |
| SIN | Support Information Network | In English | → Networks, communication → Knowledge management |
| SIO | Serial Input/Output | In English | |
| SIO | System Internetowy Olimpiady | In Polish | → Networks, communication |
| SIOgim | System Internetowy Olimpiady Gimnazjalistów | In Polish | → Networks, communication |
| SIP | Software Input Panel | In English | → Software |
| SIP | Standard Interface Plan | In English | → Human-computer interaction |
| SIP | Standard Interface Panel | In English | → Human-computer interaction |
| SIP | Session Initiation Protocol | In English | → Networks, communication → Telecommunications |
| SIPB | Student Information Processing Board | In English | → Software → Specialized or (poly)technical colleges |
| SIRA | Système d'Informations pour la Recherche en Accidentologie | In French | → Data → Transport and postal services |
| SIRENE | Système Informatique pour le Répertoire des ENtreprises et Établissements | In French | → Computer-based techniques → Economics |
| SIRR | Software Integration Readiness Review | In English | → Software |
| SIRS | Système d'Information à Référence Spatiale | In French | → Software → Geography |
| SIS | Software Intensive System | In English | → Computer-based techniques |
| SIS | Simulation Interface Subsystem | In English | → Human-computer interaction |
| SIS | SAIL Interface System | In English | → Human-computer interaction |
| SIS | Simulator Interface System | In English | → Human-computer interaction |
| SIS | Software Implementation Specification | In English | → Software |
| SIS | Standard Interface Specification | In English | → Human-computer interaction |
| SIS | Shuttle Interface Simulator | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SIS | Software Integrated Schedule | In English | → Software |
| SISD | Simulation Interface and Standards Document | In English | → Human-computer interaction |
| SISTM | Simulation of Strategies for Traffic on Motorways | In English | → Computer simulation → Transport and postal services |
| SIT | Software Integrated Test | In English | → Software |
| SIT | System Informacji o Terenie = SIT | Sistema Informativo Territoriale | In Italian = SIT | Système d'Information sur le Territoire | In French |
In Polish | → Software → Regional planning → Geography |
| SIT | Système d'Information sur le Territoire = (look above) |
In French | → Software → Regional planning → Geography |
| SIT | Sistema Informativo Territoriale = (look above) |
In Italian | → Software → Regional planning → Geography |
| SIU | Signal Interface Unit | In English | → Human-computer interaction |
| SIU | Serial Interface Unit | In English | → Human-computer interaction |
| SIU | Standard Interface Unit | In English | → Human-computer interaction |
| SL&I | System Load and Initialization | In English | |
| SLEE | Service Logic Execution Environment | In English | → Software |
| SLIP | Serial Line Internet Protocol | In English | → Networks, communication |
| SLPEM | Sparta Linear Programming Effectiveness Model | In English | → Software |
| SLS | Softlanding Linux System | In English | → Operating systems |
| SMBD | Sistem manajemen basis data = SGBD, DBMS, SŘBD, SUBP, DBKS (look above) |
In Indonesian | → Data |
| SMBL | Systems Biology Markup Language | In English | → Programming languages → Data → Biological sciences |
| SMCM | Small Module Core Memory | In English | → Memories |
| SMEK | Summary Message Enable Keyboard | In English | → Hardware |
| SMIG | Southern Minnesota Internet Group | In English | → Organizations and associations → Networks, communication |
| SMIL | Synchronized Multimedia Integration Language | In English | → Programming languages → Computer-based techniques → Cinema, movies |
| SMILES | Simplified Molecular Input Line Entry Specification | In English | → Data → Chemistry |
| SML | Spacecraft Markup Language | In English | → Programming languages → Spaceflight engineering, astronautics |
| SMOC | Simulation Mission Operation Computer | In English | → Hardware |
| SMP | Software Management Plan | In English | → Software → Management |
| SMS | Site-Managed Software | In English | → Software |
| SMS | Software Modification Sheet | In English | → Software |
| SMSC | Software Moding, Sequencing, and Control | In English | → Software |
| SMSCC | Shuttle Mission Simulator Computer Complex | In English | → Hardware → Spaceflight engineering, astronautics |
| SMTP | Simple Mail Transfer Protocol | In English | → Networks, communication |
| SMU | Software Management Utility | In English | → Software |
| SNA | System Network Architecture | In English | → Networks, communication |
| SNL | SYBYL Line Notation | In English | → Data → Chemistry |
| SNML | Salzburg NewMediaLab | In English | → Telecommunications |
| SNMP | Simple Network Management Protocol | In English | → Internet |
| SNOBOL | StriNg Oriented symBOlic Language | In English | → Programming languages |
| SOA | Service-Oriented Architecture | In English | |
| SOAP | Simple Object Access Protocol | In English | → Networks, communication |
| SOC | Simulation Operation Computer | In English | → Computer simulation |
| SOC | Service-oriented Computing | In English | → Computer-based techniques |
| SOCC | Shuttle Operations Computing Center | In English | → Spaceflight engineering, astronautics |
| SOCH | Spacelab Orbiter Common Hardware | In English | → Hardware → Spaceflight engineering, astronautics |
| SODB | Start Of Data Block | In English | → Data |
| SODS | Shuttle Operational Data Submittal | In English | → Data → Spaceflight engineering, astronautics |
| SODS | Shuttle Operational Data System | In English | → Data → Spaceflight engineering, astronautics |
| SOGITS | Senior Officials Group on Information Technology Standardization | In English | → Standardization → Food technology |
| SOIS | Spacelab/Orbiter Interface Simulator | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SOISIC | Saisie Optique Informatique de Structures Industrielles Complexes | In French | → Computer-based techniques → Engineering, technology |
| SOLAP | Spatial On Line Analytical Processing | In English | → Knowledge management → Data |
| SOMM | Software Operations and Maintenance Manual | In English | → Software |
| SOP | Subsystem Operating Program | In English | → Software |
| SOPC | System On a Programmable Chip | In English | → Hardware → Electronics |
| SP | Stored Procedure | In English | → Software → Data |
| SPA | Simple Power Analysis | In English | → Hardware |
| SPA | Software Product Assurance | In English | → Software |
| SPA | Signal Processor Assembly | In English | → Hardware → Electronics → Telecommunications |
| SPAF | Simulation Processor and Formatter | In English | → Computer simulation |
| SPAN | Services and Protocols for Advanced Networks | In English | → Networks, communication → Telecommunications |
| SPARC | Semantic Phonetic Automatic Reconstruction of Dictations | In English | → Computer-based techniques → Language, linguistics, literature |
| SPARQL | SPARQL Protocol And RDF Query Language | In English | → Data → Networks, communication |
| SPC | Stored Program Command | In English | → Software |
| SPC | Stored Program Control | In English | → Software |
| SPC | Starting-Point Code | In English | → Software |
| SPC | Software Productivity Consortium | In English | → Software |
| SPCR | Software Problem Change Request | In English | → Software |
| SPCU | Simulation Process Control Unit | In English | → Computer simulation |
| SPDIF | Sony-Philips Data Interchange Format | In English | → Networks, communication → Telecommunications |
| SPDR | Software Preliminary Design Review | In English | → Software |
| SPE | Software Process Engineering | In English | → Software |
| SPF | Software Production Facility | In English | → Software |
| SPL | System Programming Language | In English | → Programming languages |
| SPM | Software Programmer's Manual | In English | → Software |
| SPM | Software Performance Monitor | In English | → Software |
| SPOC | Shuttle Portable On-Board Computer | In English | → Hardware → Spaceflight engineering, astronautics |
| SPOM | Self Programmable One-chip Microcomputer | In English | → Hardware → Electronics → Telecommunications |
| SPP | Serial Port Profile | In English | → Hardware |
| SPR | Software Problem Report | In English | → Software → Quality management |
| SPS | Software Product Specification | In English | → Software |
| SPS | Software Productivity Solution | In English | → Software |
| SPSC | Signal Processing and Speech Communication | In English | → Document processing → Language, linguistics, literature |
| SPT | System Planning Tool | In English | → Software |
| SQA | Software Quality Assurance | In English | → Software → Quality management |
| SQALE | Speech recognizer Quality Assessment for Linguistic Engineering | In English | → Computer-based techniques → Linguistics |
| SQE | Software Quality Evaluation | In English | → Software → Quality management |
| SQIDS | Satellite Quick-Look Interactive Display System | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SQL | Structured Query Language | In English | → Data |
| SRAM | Static Random Access Memory | In English | → Memories |
| SRB | Software Review Board | In English | → Organizations and associations |
| SŘBD | Systém řízení báze dat = SGBD, DBMS, SMBD, SUBP, DBKS (look above) |
In Czech | → Data |
| SRCB | Software Requirements Change Board | In English | → Software |
| SRCBD | Software Requirements Change Board Directive | In English | → Software |
| SRD | Secondary Received Data | In English | → Data → Telecommunications |
| SREM | Software Requirements Methodology | In English | → Software |
| SRI | Syndicat des Régies Internet | In French | → Organizations and associations → 659 → Networks, communication |
| SRN | Software Release Notice | In English | → Software |
| SRR | Software Requirements Review | In English | → Software → Quality management |
| SRS | Software Requirements Specification | In English | → Software → Quality management |
| SRSCC | Simulated Remote Station Control Console | In English | → Human-computer interaction → Networks, communication |
| SRTS | Secondary Request To Send | In English | → Data → Telecommunications |
| SS | System Software | In English | → Software |
| SSA | Software Support Agency | In English | → Software |
| SSA | Software Safety Analysis | In English | → Software |
| SSAD | Software System Analysis Document | In English | → Software |
| SSBA | Svenska sällskapet för automatiserad bildanalys | In Swedish | → Organizations and associations → Graphical processing → Image processing |
| SSC | Subsystem Computer | In English | → Hardware |
| SSCR | Support Software Change Request | In English | → Software |
| SSD | Spacecraft Software Division | In English | → Software → Spaceflight engineering, astronautics |
| SSDAC | Space Station Data Acquisition and Control | In English | → Data → Spaceflight engineering, astronautics |
| SSDD | Software System Design Document | In English | → Software |
| SSDS | Space Station Data System | In English | → Data → Spaceflight engineering, astronautics |
| SSDSAS | Space Station Data System Architecture Study | In English | → Hardware → Data → Spaceflight engineering, astronautics |
| SSE | Software Support Environment | In English | → Software |
| SSE | Software Support Equipment | In English | → Software |
| SSEDF | Software Support Environment Development Facility | In English | → Software |
| SSES | Software System Environment System | In English | → Software |
| SSH | Simulation Support Hardware | In English | → Hardware → Computer simulation |
| SSH | Secure Shell | In English | → Networks, communication |
| SSI | Server Side Includes | In English | → Networks, communication |
| SSIBD | Shuttle System Interface Block Diagram | In English | → Human-computer interaction → Spaceflight engineering, astronautics |
| SSIE | Société Suisse pour l'Informatique dans l'Enseignement = SVIA | Schweizerischer Verein für Informatik in der Ausbildung | In German = SSII | Società Svizzera per l'Informatica nell'Insegnamento | In Italian |
In French | → Organizations and associations → Education |
| SSII | Società Svizzera per l'Informatica nell'Insegnamento = SSIE, SVIA (look above) |
In Italian | → Organizations and associations → Education |
| SSII | Société de Services en Ingéniérie Informatique | In French |